4OAU

Complete human RNase L in complex with biological activators.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000166	molecular_function	nucleotide binding
C	0003723	molecular_function	RNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004521	molecular_function	RNA endonuclease activity
C	0004540	molecular_function	RNA nuclease activity
C	0004672	molecular_function	protein kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0008270	molecular_function	zinc ion binding
C	0010468	biological_process	regulation of gene expression
C	0016363	cellular_component	nuclear matrix
C	0016787	molecular_function	hydrolase activity
C	0019843	molecular_function	rRNA binding
C	0043021	molecular_function	ribonucleoprotein complex binding
C	0043488	biological_process	regulation of mRNA stability
C	0045071	biological_process	negative regulation of viral genome replication
C	0045444	biological_process	fat cell differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046326	biological_process	positive regulation of D-glucose import
C	0046872	molecular_function	metal ion binding
C	0051252	biological_process	regulation of RNA metabolic process
C	0051607	biological_process	defense response to virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP C 801

Chain	Residue
C	ILE371
C	THR440
C	GLN489
C	ASN490
C	LEU492
C	ASP503
C	ASP505
C	MG802
C	MG803
C	HOH923
C	HOH925
C	ALA372
C	HOH993
C	THR374
C	ILE379
C	ALA390
C	LYS392
C	VAL434
C	THR435
C	CYS437

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 802

Chain	Residue
C	GLN487
C	ASN490
C	ASP503
C	ADP801
C	MG803
C	HOH923

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 803

Chain	Residue
C	ASP503
C	ASP505
C	ADP801
C	MG802

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	ZN_FING: C6-type; atypical

Chain	Residue	Details
C	CYS395-CYS444

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS684

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