4OA5
X-ray crystal structure of an O-methyltransferase from Anaplasma phagocytophilum bound to SAH solved by iodide SAD phasing
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008150 | biological_process | biological_process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0008150 | biological_process | biological_process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0008150 | biological_process | biological_process |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008171 | molecular_function | O-methyltransferase activity |
| C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| D | 0008150 | biological_process | biological_process |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008171 | molecular_function | O-methyltransferase activity |
| D | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| D | 0032259 | biological_process | methylation |
| E | 0008150 | biological_process | biological_process |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0008171 | molecular_function | O-methyltransferase activity |
| E | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| E | 0032259 | biological_process | methylation |
| F | 0008150 | biological_process | biological_process |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0008171 | molecular_function | O-methyltransferase activity |
| F | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| F | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH A 301 |
| Chain | Residue |
| A | GLN39 |
| A | ASN93 |
| A | GLY115 |
| A | GLU116 |
| A | ALA117 |
| A | ASP136 |
| A | ALA137 |
| A | ASN138 |
| A | TYR145 |
| A | HOH401 |
| A | HOH509 |
| A | LEU40 |
| A | GLY64 |
| A | THR65 |
| A | CYS66 |
| A | PHE69 |
| A | SER70 |
| A | GLU88 |
| A | LYS89 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 304 |
| Chain | Residue |
| A | MET47 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 305 |
| Chain | Residue |
| A | HIS76 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 306 |
| Chain | Residue |
| A | GLY23 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 308 |
| Chain | Residue |
| A | HIS58 |
| A | IOD309 |
| A | HOH491 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IOD A 309 |
| Chain | Residue |
| A | PRO79 |
| A | LYS81 |
| A | TYR85 |
| A | MET127 |
| A | IOD308 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 312 |
| Chain | Residue |
| A | IOD313 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 313 |
| Chain | Residue |
| A | LYS155 |
| A | IOD312 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 317 |
| Chain | Residue |
| A | ASN98 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 318 |
| Chain | Residue |
| A | ASN147 |
| A | LYS150 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 319 |
| Chain | Residue |
| D | LEU118 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 320 |
| Chain | Residue |
| A | GLN9 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 321 |
| Chain | Residue |
| A | ASP192 |
| A | HOH407 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 322 |
| Chain | Residue |
| A | GLN9 |
| A | HOH530 |
| A | HOH531 |
| F | PHE165 |
| F | PRO206 |
| F | THR207 |
| F | SER208 |
| site_id | BC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH B 301 |
| Chain | Residue |
| B | GLN39 |
| B | LEU40 |
| B | GLY64 |
| B | THR65 |
| B | CYS66 |
| B | PHE69 |
| B | SER70 |
| B | GLU88 |
| B | LYS89 |
| B | ASN93 |
| B | GLY115 |
| B | GLU116 |
| B | ALA117 |
| B | ASP136 |
| B | ALA137 |
| B | ASN138 |
| B | TYR145 |
| B | HOH417 |
| B | HOH487 |
| B | HOH514 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 302 |
| Chain | Residue |
| B | HOH479 |
| F | ASN147 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 303 |
| Chain | Residue |
| B | GLY156 |
| B | IOD315 |
| B | IOD316 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 304 |
| Chain | Residue |
| B | ARG53 |
| C | HOH510 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 305 |
| Chain | Residue |
| B | GLN49 |
| B | ARG53 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 306 |
| Chain | Residue |
| B | LYS155 |
| B | HOH513 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 307 |
| Chain | Residue |
| B | GLY23 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 313 |
| Chain | Residue |
| B | THR207 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 315 |
| Chain | Residue |
| B | IOD303 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 316 |
| Chain | Residue |
| B | IOD303 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 317 |
| Chain | Residue |
| D | LYS26 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 318 |
| Chain | Residue |
| B | PHE171 |
| B | HOH517 |
| C | LYS8 |
| C | TYR12 |
| site_id | CC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH C 301 |
| Chain | Residue |
| C | ALA117 |
| C | ASP136 |
| C | ALA137 |
| C | ASN138 |
| C | HOH413 |
| C | HOH479 |
| C | HOH480 |
| C | GLN39 |
| C | LEU40 |
| C | GLY64 |
| C | THR65 |
| C | CYS66 |
| C | PHE69 |
| C | SER70 |
| C | GLU88 |
| C | LYS89 |
| C | ASN93 |
| C | GLY115 |
| C | GLU116 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 302 |
| Chain | Residue |
| B | HOH517 |
| C | LYS15 |
| site_id | DC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 303 |
| Chain | Residue |
| C | MET47 |
| site_id | DC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 304 |
| Chain | Residue |
| C | GLY23 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 305 |
| Chain | Residue |
| C | IOD306 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 306 |
| Chain | Residue |
| C | ASN138 |
| C | IOD305 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD C 307 |
| Chain | Residue |
| C | SER33 |
| C | ALA183 |
| C | IOD308 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 308 |
| Chain | Residue |
| C | SER180 |
| C | IOD307 |
| site_id | DC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 309 |
| Chain | Residue |
| C | HIS76 |
| site_id | DC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 310 |
| Chain | Residue |
| C | LYS81 |
| site_id | EC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 311 |
| Chain | Residue |
| C | HIS58 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD C 312 |
| Chain | Residue |
| C | LEU118 |
| C | SER141 |
| E | LEU118 |
| E | SER141 |
| site_id | EC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 313 |
| Chain | Residue |
| C | ASN147 |
| C | IOD314 |
| site_id | EC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD C 314 |
| Chain | Residue |
| C | ASN147 |
| C | IOD313 |
| E | ASN122 |
| site_id | EC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 315 |
| Chain | Residue |
| C | HOH532 |
| site_id | EC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 318 |
| Chain | Residue |
| C | ASN182 |
| site_id | EC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 320 |
| Chain | Residue |
| C | LYS155 |
| site_id | EC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH D 301 |
| Chain | Residue |
| D | GLN39 |
| D | LEU40 |
| D | GLY64 |
| D | THR65 |
| D | CYS66 |
| D | PHE69 |
| D | SER70 |
| D | GLU88 |
| D | LYS89 |
| D | ASN93 |
| D | GLY115 |
| D | GLU116 |
| D | ALA117 |
| D | ASP136 |
| D | ALA137 |
| D | ASN138 |
| D | TYR145 |
| D | IOD304 |
| D | HOH403 |
| site_id | EC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD D 304 |
| Chain | Residue |
| D | GLU116 |
| D | LEU118 |
| D | TYR145 |
| D | SAH301 |
| site_id | FC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 305 |
| Chain | Residue |
| D | GLU116 |
| site_id | FC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 308 |
| Chain | Residue |
| E | HOH516 |
| site_id | FC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 309 |
| Chain | Residue |
| D | GLY23 |
| site_id | FC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 310 |
| Chain | Residue |
| D | MET37 |
| site_id | FC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 311 |
| Chain | Residue |
| D | HIS58 |
| D | HOH463 |
| site_id | FC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 312 |
| Chain | Residue |
| D | LYS81 |
| site_id | FC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 313 |
| Chain | Residue |
| D | IOD314 |
| site_id | FC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 314 |
| Chain | Residue |
| D | IOD313 |
| site_id | FC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 315 |
| Chain | Residue |
| D | HIS174 |
| site_id | GC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 316 |
| Chain | Residue |
| D | HOH504 |
| site_id | GC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 317 |
| Chain | Residue |
| D | ARG188 |
| E | EDO318 |
| site_id | GC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 318 |
| Chain | Residue |
| D | GLU22 |
| D | IOD319 |
| site_id | GC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 319 |
| Chain | Residue |
| D | IOD318 |
| site_id | GC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD D 320 |
| Chain | Residue |
| D | LYS139 |
| D | SER140 |
| D | HOH410 |
| site_id | GC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 321 |
| Chain | Residue |
| D | LYS155 |
| site_id | GC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 323 |
| Chain | Residue |
| A | LEU118 |
| D | SER180 |
| D | SER181 |
| D | ASN182 |
| site_id | GC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 324 |
| Chain | Residue |
| D | VAL95 |
| D | ASN98 |
| D | GLN99 |
| D | VAL102 |
| D | HOH550 |
| E | GLY56 |
| E | HIS58 |
| site_id | GC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH E 301 |
| Chain | Residue |
| E | GLN39 |
| E | LEU40 |
| E | GLY64 |
| E | THR65 |
| E | CYS66 |
| E | PHE69 |
| E | SER70 |
| E | GLU88 |
| E | LYS89 |
| E | ASN93 |
| E | GLY115 |
| E | GLU116 |
| E | ALA117 |
| E | ASP136 |
| E | ALA137 |
| E | ASN138 |
| E | IOD317 |
| E | HOH418 |
| E | HOH465 |
| E | HOH504 |
| site_id | HC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 302 |
| Chain | Residue |
| E | IOD303 |
| site_id | HC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD E 303 |
| Chain | Residue |
| E | ASN138 |
| E | IOD302 |
| site_id | HC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 304 |
| Chain | Residue |
| E | SER180 |
| site_id | HC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 306 |
| Chain | Residue |
| E | GLY23 |
| site_id | HC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 307 |
| Chain | Residue |
| E | HOH525 |
| site_id | HC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 309 |
| Chain | Residue |
| E | MET47 |
| site_id | HC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 310 |
| Chain | Residue |
| E | HIS76 |
| site_id | HC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD E 311 |
| Chain | Residue |
| C | ASN122 |
| C | LYS125 |
| E | ASN147 |
| E | IOD312 |
| site_id | HC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD E 312 |
| Chain | Residue |
| E | ASN147 |
| E | IOD311 |
| site_id | IC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 313 |
| Chain | Residue |
| E | GLU116 |
| site_id | IC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 314 |
| Chain | Residue |
| E | HOH495 |
| site_id | IC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD E 315 |
| Chain | Residue |
| E | ARG36 |
| site_id | IC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD E 317 |
| Chain | Residue |
| C | HOH507 |
| E | LYS89 |
| E | SAH301 |
| site_id | IC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 318 |
| Chain | Residue |
| D | PHE171 |
| D | IOD317 |
| E | TYR12 |
| E | HOH524 |
| site_id | IC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 319 |
| Chain | Residue |
| E | MET37 |
| E | GLN39 |
| E | GLU209 |
| E | HOH487 |
| site_id | IC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL E 320 |
| Chain | Residue |
| E | SER80 |
| E | LYS109 |
| site_id | IC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH F 301 |
| Chain | Residue |
| F | GLN39 |
| F | LEU40 |
| F | GLY64 |
| F | CYS66 |
| F | PHE69 |
| F | SER70 |
| F | GLU88 |
| F | LYS89 |
| F | ASN93 |
| F | GLY115 |
| F | GLU116 |
| F | ALA117 |
| F | ASP136 |
| F | ALA137 |
| F | ASN138 |
| F | TYR145 |
| F | HOH403 |
| F | HOH516 |
| F | HOH522 |
| site_id | IC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD F 303 |
| Chain | Residue |
| F | HOH511 |
| site_id | JC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD F 304 |
| Chain | Residue |
| F | GLY23 |
| site_id | JC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD F 306 |
| Chain | Residue |
| B | PRO175 |
| site_id | JC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD F 310 |
| Chain | Residue |
| F | THR176 |
| F | LYS178 |
| F | VAL179 |
| F | HOH525 |
| site_id | JC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD F 311 |
| Chain | Residue |
| F | MET47 |
| F | THR207 |
| site_id | JC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD F 312 |
| Chain | Residue |
| F | LYS81 |
| site_id | JC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD F 313 |
| Chain | Residue |
| B | LYS81 |
| F | HOH506 |
| site_id | JC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD F 314 |
| Chain | Residue |
| F | GLU116 |
| site_id | JC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD F 315 |
| Chain | Residue |
| F | PRO79 |
| site_id | JC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD F 317 |
| Chain | Residue |
| F | SER140 |
| F | HOH498 |
| site_id | KC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD F 318 |
| Chain | Residue |
| B | HOH424 |
| F | ASN147 |
| site_id | KC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD F 319 |
| Chain | Residue |
| A | HOH439 |
| A | HOH544 |
| site_id | KC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD F 321 |
| Chain | Residue |
| F | LYS155 |
| F | HOH456 |
| site_id | KC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO F 324 |
| Chain | Residue |
| B | ASN182 |
| B | ALA185 |
| B | SER186 |
| B | HOH522 |
| F | SER140 |
| F | HOH405 |
| F | HOH408 |
| F | HOH499 |
| site_id | KC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO F 325 |
| Chain | Residue |
| F | LEU25 |
| F | HIS28 |
| F | HOH491 |
| site_id | KC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO F 326 |
| Chain | Residue |
| F | LYS26 |
| F | LYS29 |
| F | THR30 |
| F | HOH475 |
| site_id | KC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 327 |
| Chain | Residue |
| B | GLU173 |
| B | HIS174 |
| F | LEU118 |
| F | ASN122 |
| F | TRP148 |
| F | MET151 |
| F | HOH423 |
| site_id | KC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 328 |
| Chain | Residue |
| F | GLU44 |
| F | THR207 |
| F | SER208 |
| F | GLU209 |
| F | HOH448 |
| F | HOH527 |
| site_id | KC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL F 329 |
| Chain | Residue |
| F | ASP192 |
| F | ALA195 |
| F | ASN196 |
