4O9U

Mechanism of transhydrogenase coupling proton translocation and hydride transfer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006740	biological_process	NADPH regeneration
A	0008750	molecular_function	proton-translocating NAD(P)+ transhydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0050661	molecular_function	NADP binding
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0008750	molecular_function	proton-translocating NAD(P)+ transhydrogenase activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0050661	molecular_function	NADP binding
B	1902600	biological_process	proton transmembrane transport
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006740	biological_process	NADPH regeneration
C	0008750	molecular_function	proton-translocating NAD(P)+ transhydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0050661	molecular_function	NADP binding
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0008750	molecular_function	proton-translocating NAD(P)+ transhydrogenase activity
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0050661	molecular_function	NADP binding
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006740	biological_process	NADPH regeneration
E	0016491	molecular_function	oxidoreductase activity
E	0050661	molecular_function	NADP binding
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0006740	biological_process	NADPH regeneration
F	0016491	molecular_function	oxidoreductase activity
F	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAP B 500

Chain	Residue
B	GLY302
B	GLY375
B	ALA376
B	ASN377
B	ASP378
B	VAL379
B	LYS409
B	ARG410
B	GLY411
B	GLY413
B	LYS414
B	LEU305
B	GLY415
B	PHE416
B	GLY434
B	ASP435
B	ALA436
E	THR124
E	GLN127
B	SER306
B	VAL333
B	ALA334
B	GLY335
B	ARG336
B	MET337
B	PRO338

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site_id	AC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP D 500

Chain	Residue
D	GLY201
D	ASP202
D	PRO204
D	MET252
D	ASN253
D	ARG254
D	GLY302
D	LEU305
D	SER306
D	VAL333
D	ALA334
D	GLY335
D	ARG336
D	MET337
D	GLY375
D	ALA376
D	ASN377
D	ASP378
D	VAL379
D	LYS409
D	ARG410
D	GLY411
D	GLY413
D	LYS414
D	GLY415
D	PHE416
D	GLY434
D	ASP435
D	ALA436

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NAD E 500

Chain	Residue
E	LEU132
E	GLY174
E	VAL175
E	GLY176
E	TYR196
E	ASP197
E	LYS235
E	THR255
E	ALA256
E	LEU266

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site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD F 500

Chain	Residue
F	ARG122
F	GLN127
F	GLY174
F	VAL175
F	GLY176
F	VAL177
F	TYR196
F	ASP197
F	ARG199
F	GLN238
F	THR255
F	ALA256
F	GLN257
F	LEU266

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Functional Information from PROSITE/UniProt

site_id	PS00837
Number of Residues	26
Details	ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VMGVGvAGlmAiatAkRLGAqVfayD

Chain	Residue	Details
E	VAL172-ASP197

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