4O82
SAICAR synthetase (Type-1) in complex with ADP AND AMP in both chains
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 301 |
| Chain | Residue |
| A | GLU158 |
| A | ASP162 |
| B | GLU158 |
| B | ASP162 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD A 302 |
| Chain | Residue |
| A | GLU89 |
| A | ASP128 |
| A | AMP307 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 303 |
| Chain | Residue |
| A | ASP35 |
| A | HIS127 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD A 304 |
| Chain | Residue |
| A | GLU89 |
| A | AMP307 |
| A | HOH449 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD A 305 |
| Chain | Residue |
| A | LYS13 |
| A | ASP190 |
| A | CD306 |
| A | ADP308 |
| A | HOH446 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD A 306 |
| Chain | Residue |
| A | CD305 |
| A | AMP307 |
| A | HOH446 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AMP A 307 |
| Chain | Residue |
| A | GLU89 |
| A | ARG93 |
| A | GLY98 |
| A | SER99 |
| A | ASP173 |
| A | PHE174 |
| A | LYS175 |
| A | ASP195 |
| A | THR196 |
| A | CYS197 |
| A | ARG198 |
| A | ARG214 |
| A | CD302 |
| A | CD304 |
| A | CD306 |
| A | HOH418 |
| A | HOH449 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP A 308 |
| Chain | Residue |
| A | ALA12 |
| A | LYS13 |
| A | MSE15 |
| A | HIS68 |
| A | GLU81 |
| A | LEU83 |
| A | MSE85 |
| A | LYS122 |
| A | GLU177 |
| A | ASP190 |
| A | CD305 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 401 |
| Chain | Residue |
| A | HIS63 |
| B | GLU111 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 402 |
| Chain | Residue |
| A | GLU111 |
| B | HIS63 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 403 |
| Chain | Residue |
| B | GLU89 |
| B | ASP124 |
| B | ASP128 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 404 |
| Chain | Residue |
| B | ASP35 |
| B | HIS127 |
| B | HOH526 |
| B | HOH527 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 405 |
| Chain | Residue |
| B | GLU81 |
| B | ASP181 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 406 |
| Chain | Residue |
| A | ASP19 |
| A | ASP21 |
| B | GLU125 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD B 407 |
| Chain | Residue |
| B | GLU226 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 408 |
| Chain | Residue |
| B | GLU89 |
| B | AMP411 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD B 409 |
| Chain | Residue |
| B | LYS13 |
| B | ASP190 |
| B | CD410 |
| B | ADP412 |
| B | HOH550 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 410 |
| Chain | Residue |
| B | CD409 |
| B | AMP411 |
| B | HOH550 |
| site_id | CC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP B 411 |
| Chain | Residue |
| B | GLU89 |
| B | VAL91 |
| B | ARG93 |
| B | GLY98 |
| B | SER99 |
| B | ASP173 |
| B | PHE174 |
| B | LYS175 |
| B | ASP195 |
| B | THR196 |
| B | CYS197 |
| B | ARG198 |
| B | CD408 |
| B | CD410 |
| site_id | CC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ADP B 412 |
| Chain | Residue |
| B | HOH537 |
| B | HOH550 |
| B | LYS13 |
| B | MSE15 |
| B | HIS68 |
| B | GLU81 |
| B | LEU83 |
| B | MSE85 |
| B | LYS122 |
| B | GLU177 |
| B | ASP190 |
| B | CD409 |
Functional Information from PROSITE/UniProt
