4O6F

Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000993	molecular_function	RNA polymerase II complex binding
A	0002039	molecular_function	p53 binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0007507	biological_process	heart development
A	0008168	molecular_function	methyltransferase activity
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016278	molecular_function	lysine N-methyltransferase activity
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0018026	biological_process	peptidyl-lysine monomethylation
A	0018027	biological_process	peptidyl-lysine dimethylation
A	0032259	biological_process	methylation
A	0042054	molecular_function	histone methyltransferase activity
A	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
A	0046872	molecular_function	metal ion binding
A	0046975	molecular_function	histone H3K36 methyltransferase activity
A	0140938	molecular_function	histone H3 methyltransferase activity
A	0140999	molecular_function	histone H3K4 trimethyltransferase activity
A	1901796	biological_process	regulation of signal transduction by p53 class mediator

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS52
A	CYS55
A	CYS74
A	CYS78

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS65
A	CYS68
A	HIS86
A	CYS90

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS262
A	CYS264
A	CYS267
A	CYS209

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH A 504

Chain	Residue
A	GLY16
A	LYS17
A	ARG19
A	HIS137
A	ASN182
A	ALA203
A	ASN206
A	HIS207
A	TYR240
A	TYR258
A	PHE260
A	HOH615

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PE8 A 505

Chain	Residue
A	GLU190
A	LYS309
A	TYR344
A	GLY348
A	LEU351
A	TRP356
A	LYS387
A	HOH661
B	ARG269

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NI A 506

Chain	Residue
A	CYS13

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NI A 507

Chain	Residue
A	CYS210
A	HOH665

---

Functional Information from PROSITE/UniProt

site_id	PS01360
Number of Residues	40
Details	ZF_MYND_1 Zinc finger MYND-type signature. Hcey.Cftrkeglsk........CgrCkqafYCnveCqkedwpm..Hkle.C

Chain	Residue	Details
A	HIS51-CYS90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	ZN_FING: MYND-type => ECO:0000255|PROSITE-ProRule:PRU00134

Chain	Residue	Details
A	CYS52-CYS90

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	LYS17
A	ASN206
A	TYR258

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00134

Chain	Residue	Details
A	CYS52
A	CYS55
A	CYS65
A	CYS68
A	CYS74
A	CYS78
A	HIS86
A	CYS90

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:21724641

Chain	Residue	Details
A	HIS137

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER283

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