4O61
Structure of human ALKBH5 crystallized in the presence of citrate
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 301 |
| Chain | Residue |
| A | GLU263 |
| A | THR265 |
| A | HOH411 |
| A | HOH487 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CIT A 302 |
| Chain | Residue |
| A | ILE215 |
| A | SER217 |
| A | HIS266 |
| A | ILE281 |
| A | ARG283 |
| A | HOH416 |
| A | LYS132 |
| A | ASN193 |
| A | ILE201 |
| A | HIS204 |
| A | ASP206 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 301 |
| Chain | Residue |
| B | ALA114 |
| B | GLY117 |
| B | LEU118 |
| B | TYR119 |
| B | VAL124 |
| B | ARG126 |
| B | HOH404 |
| B | HOH486 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CIT B 302 |
| Chain | Residue |
| B | LYS132 |
| B | ASN193 |
| B | ILE201 |
| B | HIS204 |
| B | ASP206 |
| B | ILE215 |
| B | SER217 |
| B | HIS266 |
| B | ILE281 |
| B | ARG283 |
| B | HOH406 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:35333330 |
| Chain | Residue | Details |
| A | TYR139 | |
| B | TYR139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:35333330, ECO:0007744|PDB:4NRO, ECO:0007744|PDB:4OCT, ECO:0007744|PDB:7WKV |
| Chain | Residue | Details |
| A | ASN193 | |
| A | TYR195 | |
| A | ARG277 | |
| B | ASN193 | |
| B | TYR195 | |
| B | ARG277 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24616105, ECO:0000305|PubMed:24778178, ECO:0000305|PubMed:35333330, ECO:0007744|PDB:7V4G, ECO:0007744|PDB:7WKV, ECO:0007744|PDB:7WL0 |
| Chain | Residue | Details |
| A | HIS204 | |
| A | ASP206 | |
| A | HIS266 | |
| B | HIS204 | |
| B | ASP206 | |
| B | HIS266 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000269|PubMed:34048572 |
| Chain | Residue | Details |
| A | SER87 | |
| B | SER87 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS132 | |
| B | LYS132 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:37369679 |
| Chain | Residue | Details |
| A | LYS235 | |
| B | LYS235 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:34048572 |
| Chain | Residue | Details |
| A | LYS86 | |
| B | LYS86 |
