4O5U
Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000302 | biological_process | response to reactive oxygen species |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008785 | molecular_function | alkyl hydroperoxide reductase activity |
| A | 0009321 | cellular_component | alkyl hydroperoxide reductase complex |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071949 | molecular_function | FAD binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0102039 | molecular_function | NADH-dependent peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | PRO453 |
| A | ASN454 |
| A | THR455 |
| A | ASN456 |
| A | TRP457 |
| A | HOH767 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | GLN336 |
| A | GLY333 |
| A | GLU334 |
| A | ASP335 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | ASP473 |
| A | ALA474 |
| site_id | AC4 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 604 |
| Chain | Residue |
| A | GLY219 |
| A | GLY221 |
| A | PRO222 |
| A | ALA223 |
| A | TYR230 |
| A | GLY242 |
| A | GLU243 |
| A | ARG244 |
| A | GLY247 |
| A | GLN248 |
| A | THR252 |
| A | ASN257 |
| A | GLN288 |
| A | SER289 |
| A | ALA290 |
| A | ALA321 |
| A | THR322 |
| A | GLY323 |
| A | ALA324 |
| A | TRP326 |
| A | CYS348 |
| A | TRP457 |
| A | GLY487 |
| A | ASP488 |
| A | LYS495 |
| A | GLN496 |
| A | ILE497 |
| A | ALA500 |
| A | HOH706 |
| A | HOH717 |
| A | HOH727 |
| A | HOH728 |
| A | HOH792 |
| A | HOH794 |
| A | HOH814 |
| A | HOH815 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | HIS438 |
| A | ASN439 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | GLY364 |
| A | ASN365 |
| A | SER366 |
| A | HOH751 |
| A | HOH795 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | ARG357 |
| A | HIS380 |
| A | HOH777 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | ASP393 |
| A | GLN394 |
| A | HOH718 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 609 |
| Chain | Residue |
| A | TRP326 |
| A | TYR344 |
| A | VAL447 |
| A | GLN448 |
| A | GLY450 |
| A | LEU451 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 610 |
| Chain | Residue |
| A | HIS85 |
| A | HIS130 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CphCDGpl..FkgkrVaVIGGGN |
| Chain | Residue | Details |
| A | CYS345-ASN365 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
