4O5G
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | ASP58 |
| A | HIS180 |
| A | HIS216 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 402 |
| Chain | Residue |
| A | ASP14 |
| A | HIS16 |
| A | ASP58 |
| A | HIS216 |
| A | HIS218 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2PV A 403 |
| Chain | Residue |
| A | ASP58 |
| A | LEU60 |
| A | HIS61 |
| A | SER62 |
| A | ARG63 |
| A | PRO91 |
| A | GLY92 |
| A | ASN93 |
| A | GLY57 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | ASP58 |
| B | HIS180 |
| B | HIS216 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 402 |
| Chain | Residue |
| B | ASP14 |
| B | HIS16 |
| B | ASP58 |
| B | HIS216 |
| B | HIS218 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2PV B 403 |
| Chain | Residue |
| B | GLY57 |
| B | ASP58 |
| B | LEU59 |
| B | LEU60 |
| B | SER62 |
| B | ARG63 |
| B | PRO91 |
| B | GLY92 |
| B | ASN93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8U1N9, ECO:0000255|HAMAP-Rule:MF_02044 |
| Chain | Residue | Details |
| A | HIS94 | |
| B | HIS94 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G |
| Chain | Residue | Details |
| A | ASP14 | |
| A | HIS16 | |
| A | ASP58 | |
| A | HIS216 | |
| B | ASP14 | |
| B | HIS16 | |
| B | ASP58 | |
| B | HIS216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O4K |
| Chain | Residue | Details |
| A | HIS180 | |
| B | HIS180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:4NZV |
| Chain | Residue | Details |
| A | HIS218 | |
| B | HIS218 |
