4O3M

Ternary complex of Bloom's syndrome helicase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0043138	molecular_function	3'-5' DNA helicase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1301

Chain	Residue
A	ADP1303
A	HOH1403
A	HOH1404
A	HOH1443

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1302

Chain	Residue
A	CYS1036
A	CYS1055
A	CYS1063
A	CYS1066

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP A 1303

Chain	Residue
A	ASN667
A	ARG669
A	GLN672
A	PRO690
A	THR691
A	GLY692
A	GLY693
A	GLY694
A	LYS695
A	SER696
A	ASN1242
A	ASP1264
A	CA1301
A	HOH1402
A	HOH1403
A	HOH1405
A	HOH1408
A	LEU665

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1304

Chain	Residue
A	THR691
A	GLY692
A	ARG859
A	ASN861
A	GLY981

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1305

Chain	Residue
A	HIS660
A	GLY664
A	HIS666
A	LEU1261
A	VAL1266
A	HOH1420

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1306

Chain	Residue
A	LYS787
A	LEU788
A	LEU789
A	SER823

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1307

Chain	Residue
A	HIS641
A	PRO850
A	GLN851
A	VAL852
A	ALA1276
A	GLN1283

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1308

Chain	Residue
A	ARG836
A	ASP840
A	GLU1224

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1309

Chain	Residue
A	ASN936
A	GLY1230
A	LYS1231
A	VAL1235
A	HOH1419

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1310

Chain	Residue
A	LYS653
A	MET656
A	LYS657
A	HIS660

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1311

Chain	Residue
A	ASN1048
A	LYS1284
A	TRP1288
A	HOH1441

---

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ArFVIDEAHC

Chain	Residue	Details
A	ALA790-CYS799

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Region: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Region: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Region: {"description":"Necessary for ssDNA and DNA Holliday junction binding","evidences":[{"source":"PubMed","id":"20639533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"3' overhang DNA-binding; via amide nitrogen","evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Site: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---