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4O25

Structure of Wild Type Mus musculus Rheb bound to GTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000287molecular_functionmagnesium ion binding
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0005681cellular_componentspliceosomal complex
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0012505cellular_componentendomembrane system
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019901molecular_functionprotein kinase binding
A0030295molecular_functionprotein kinase activator activity
A0030425cellular_componentdendrite
A0031669biological_processcellular response to nutrient levels
A0032006biological_processregulation of TOR signaling
A0032008biological_processpositive regulation of TOR signaling
A0043025cellular_componentneuronal cell body
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0098978cellular_componentglutamatergic synapse
A0099175biological_processregulation of postsynapse organization
A0120163biological_processnegative regulation of cold-induced thermogenesis
A1904263biological_processpositive regulation of TORC1 signaling
A2000074biological_processregulation of type B pancreatic cell development
B0000139cellular_componentGolgi membrane
B0000287molecular_functionmagnesium ion binding
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0005681cellular_componentspliceosomal complex
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0012505cellular_componentendomembrane system
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0019901molecular_functionprotein kinase binding
B0030295molecular_functionprotein kinase activator activity
B0030425cellular_componentdendrite
B0031669biological_processcellular response to nutrient levels
B0032006biological_processregulation of TOR signaling
B0032008biological_processpositive regulation of TOR signaling
B0043025cellular_componentneuronal cell body
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0098978cellular_componentglutamatergic synapse
B0099175biological_processregulation of postsynapse organization
B0120163biological_processnegative regulation of cold-induced thermogenesis
B1904263biological_processpositive regulation of TORC1 signaling
B2000074biological_processregulation of type B pancreatic cell development
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GTP A 201
ChainResidue
AARG15
AASP33
ATYR35
APRO37
AGLY63
AASN119
ALYS120
AASP122
ALEU123
ASER149
AALA150
ASER16
AMG202
AHOH322
AHOH373
AVAL17
AGLY18
ALYS19
ASER20
ASER21
APHE31
AVAL32

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 202
ChainResidue
ALYS19
ASER20
AASP60
ATHR61
AGTP201
AHOH373

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 201
ChainResidue
BSER20
BASP36
BTHR38
BGTP202

site_idAC4
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GTP B 202
ChainResidue
BARG15
BSER16
BVAL17
BGLY18
BLYS19
BSER20
BSER21
BPHE31
BVAL32
BASP33
BTYR35
BPRO37
BTHR38
BGLY63
BASN119
BLYS120
BASP122
BLEU123
BSER149
BALA150
BMG201
BHOH305
BHOH309
BHOH315
BHOH347

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:24648513, ECO:0007744|PDB:4O25, ECO:0007744|PDB:4O2L
ChainResidueDetails
ASER16
AASN119
AASP122
AALA150
BSER16
BVAL17
BGLY18
BLYS19
BSER21
BVAL32
BASP33
AVAL17
BTYR35
BPRO37
BASN119
BASP122
BALA150
AGLY18
ALYS19
ASER21
AVAL32
AASP33
ATYR35
APRO37

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24648513
ChainResidueDetails
ASER20
BSER20

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q15382
ChainResidueDetails
ATHR38
BTHR38

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:24648513, ECO:0007744|PDB:4O25
ChainResidueDetails
AGLY63
ALYS120
BGLY63
BLYS120

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for autoinhibition of GTPase activity => ECO:0000250|UniProtKB:Q15382
ChainResidueDetails
ATYR35
BTYR35

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:21336308
ChainResidueDetails
ASER130
BSER130

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q15382
ChainResidueDetails
ALYS8
BLYS8

222624

PDB entries from 2024-07-17

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