4O2L
Structure of Mus musculus Rheb G63A mutant bound to GTP
Summary for 4O2L
Entry DOI | 10.2210/pdb4o2l/pdb |
Related | 4O25 4O2R |
Descriptor | GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | small gtpase, hydrolase, gdp and gtp |
Biological source | Mus musculus (mouse) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : Q921J2 |
Total number of polymer chains | 2 |
Total formula weight | 39692.07 |
Authors | Mazhab-Jafari, M.T.,Marshall, C.B.,Ho, J.,Ishiyama, N.,Stambolic, V.,Ikura, M. (deposition date: 2013-12-17, release date: 2014-03-26, Last modification date: 2024-02-28) |
Primary citation | Mazhab-Jafari, M.T.,Marshall, C.B.,Ho, J.,Ishiyama, N.,Stambolic, V.,Ikura, M. Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289:12195-12201, 2014 Cited by PubMed: 24648513DOI: 10.1074/jbc.C113.543736 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report