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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4O1P

Crystal Structure of RNase L in complex with 2-5A and AMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004540	molecular_function	RNA nuclease activity
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004540	molecular_function	RNA nuclease activity
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006397	biological_process	mRNA processing
B	0006468	biological_process	protein phosphorylation
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0004540	molecular_function	RNA nuclease activity
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004540	molecular_function	RNA nuclease activity
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006397	biological_process	mRNA processing
D	0006468	biological_process	protein phosphorylation
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP A 901

Chain	Residue
A	ALA370
A	GLN486
A	ASN487
A	LEU489
A	ASP500
A	ASP502
A	MG902
A	MG903
A	HOH1046
A	HOH1084
A	THR372
A	ALA373
A	ILE377
A	ALA388
A	LYS390
A	ALA433
A	CYS435
A	THR438

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 902

Chain	Residue
A	ASP500
A	ASP502
A	ANP901
A	MG903

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 903

Chain	Residue
A	ASN487
A	ASP500
A	ANP901
A	MG902
A	HOH1046

site_id	AC4
Number of Residues	28
Details	BINDING SITE FOR RESIDUE 25L A 904

Chain	Residue
A	TRP56
A	TRP58
A	SER63
A	GLN66
A	LYS87
A	ASN89
A	ILE99
A	ASN122
A	PHE124
A	GLU129
A	TYR133
A	ARG153
A	LYS164
A	HOH1002
A	HOH1020
A	HOH1024
A	HOH1028
A	HOH1035
A	HOH1052
A	HOH1064
A	HOH1112
A	HOH1222
B	ARG307
B	ARG308
B	TYR310
B	ARG353
B	PHE362
B	HOH1089

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP B 901

Chain	Residue
B	ALA370
B	THR372
B	ALA373
B	ILE377
B	ALA388
B	LYS390
B	ALA433
B	CYS435
B	THR438
B	GLN486
B	ASN487
B	LEU489
B	ASP500
B	ASP502
B	MG902
B	MG903
B	HOH1023
B	HOH1076

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 902

Chain	Residue
B	ARG398
B	ASP500
B	ASP502
B	ANP901
B	MG903

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 903

Chain	Residue
B	ASN487
B	ASP500
B	ANP901
B	MG902

site_id	AC8
Number of Residues	28
Details	BINDING SITE FOR RESIDUE 25L B 904

Chain	Residue
B	GLU129
B	TYR133
B	ARG153
B	LYS164
B	HOH1003
B	HOH1012
B	HOH1102
B	HOH1122
B	HOH1140
B	HOH1165
B	HOH1233
A	ARG307
A	ARG308
A	TYR310
A	ARG353
A	PHE362
A	HOH1071
A	HOH1110
B	TRP56
B	TRP58
B	SER63
B	GLN66
B	LYS87
B	ASN89
B	ILE99
B	ASP120
B	ASN122
B	PHE124

site_id	AC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ANP C 901

Chain	Residue
C	ALA370
C	THR372
C	ALA373
C	ILE377
C	ALA388
C	LYS390
C	ALA433
C	CYS435
C	THR438
C	GLN486
C	ASN487
C	LEU489
C	ASP500
C	ASP502
C	MG902
C	MG903
C	HOH1011
C	HOH1023
C	HOH1056
C	HOH1072
C	HOH1194

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 902

Chain	Residue
C	ASP500
C	ASP502
C	ANP901
C	MG903
C	HOH1011

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 903

Chain	Residue
C	ASN487
C	ASP500
C	ANP901
C	MG902

site_id	BC3
Number of Residues	33
Details	BINDING SITE FOR RESIDUE 25L C 904

Chain	Residue
C	TRP56
C	TRP58
C	SER63
C	GLN66
C	LYS87
C	ASN89
C	ASP120
C	ASN122
C	PHE124
C	GLU129
C	TYR133
C	ARG153
C	LYS164
C	HOH1003
C	HOH1005
C	HOH1007
C	HOH1021
C	HOH1048
C	HOH1052
C	HOH1059
C	HOH1087
C	HOH1100
C	HOH1108
C	HOH1148
C	HOH1208
C	HOH1216
D	ARG307
D	ARG308
D	TYR310
D	ARG353
D	PHE362
D	SER426
D	HOH1012

site_id	BC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP D 901

Chain	Residue
D	ALA370
D	THR372
D	ALA373
D	ILE377
D	ALA388
D	LYS390
D	ARG398
D	ALA433
D	CYS435
D	THR438
D	GLN486
D	ASN487
D	LEU489
D	ASP500
D	ASP502
D	MG902
D	MG903
D	HOH1132

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 902

Chain	Residue
D	GLN486
D	ASN487
D	ASP500
D	ANP901
D	MG903

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 903

Chain	Residue
D	ASP482
D	ASN487
D	ASP500
D	ANP901
D	MG902

site_id	BC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 25L D 904

Chain	Residue
C	ARG307
C	TYR310
C	ARG353
C	PHE362
C	HOH1130
D	TRP56
D	TRP58
D	SER63
D	GLN66
D	LYS87
D	ASN89
D	ASN122
D	PHE124
D	GLU129
D	TYR133
D	ARG153
D	LYS164
D	HOH1003
D	HOH1041
D	HOH1055
D	HOH1155
D	HOH1156
D	HOH1189
D	HOH1205
D	HOH1232

Functional Information from PROSITE/UniProt

site_id	PS00066
Number of Residues	15
Details	HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. KaEVdARDnMGrNaL

Chain	Residue	Details
A	LYS190-LEU204

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PDB entries from 2025-12-03

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