4NZ9
Crystal Structure of FabI from S. aureus in complex with a novel benzimidazole inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1JT A 301 |
| Chain | Residue |
| A | ALA97 |
| A | TYR147 |
| A | GLN155 |
| A | TYR157 |
| A | SER197 |
| A | NAP302 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP A 302 |
| Chain | Residue |
| A | SER19 |
| A | ILE20 |
| A | ARG40 |
| A | LYS41 |
| A | SER44 |
| A | ILE65 |
| A | ASP66 |
| A | VAL67 |
| A | GLN68 |
| A | SER93 |
| A | ILE94 |
| A | ALA95 |
| A | ILE120 |
| A | THR145 |
| A | THR146 |
| A | TYR147 |
| A | LYS164 |
| A | ALA190 |
| A | GLY191 |
| A | PRO192 |
| A | ILE193 |
| A | THR195 |
| A | SER197 |
| A | 1JT301 |
| A | HOH403 |
| A | HOH405 |
| A | HOH440 |
| A | HOH441 |
| A | GLY13 |
| A | ILE14 |
| A | ALA15 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1JT B 301 |
| Chain | Residue |
| B | LYS82 |
| B | ALA97 |
| B | TYR147 |
| B | VAL154 |
| B | TYR157 |
| B | SER197 |
| B | ILE207 |
| B | NAP302 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP B 302 |
| Chain | Residue |
| B | GLY13 |
| B | ILE14 |
| B | ALA15 |
| B | SER19 |
| B | ILE20 |
| B | ARG40 |
| B | LYS41 |
| B | SER44 |
| B | ILE65 |
| B | ASP66 |
| B | VAL67 |
| B | GLN68 |
| B | SER93 |
| B | ILE94 |
| B | ALA95 |
| B | ILE120 |
| B | THR145 |
| B | THR146 |
| B | LYS164 |
| B | ALA190 |
| B | GLY191 |
| B | PRO192 |
| B | ILE193 |
| B | THR195 |
| B | SER197 |
| B | 1JT301 |
| B | HOH403 |
| B | HOH404 |
| B | HOH439 |
