4NZ6
Steroid receptor RNA Activator (SRA) modification by the human Pseudouridine Synthase 1 (hPus1p): RNA binding, activity, and atomic model
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001522 | biological_process | pseudouridine synthesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0009451 | biological_process | RNA modification |
| A | 0009982 | molecular_function | pseudouridine synthase activity |
| A | 0031119 | biological_process | tRNA pseudouridine synthesis |
| B | 0001522 | biological_process | pseudouridine synthesis |
| B | 0003723 | molecular_function | RNA binding |
| B | 0009451 | biological_process | RNA modification |
| B | 0009982 | molecular_function | pseudouridine synthase activity |
| B | 0031119 | biological_process | tRNA pseudouridine synthesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 401 |
| Chain | Residue |
| A | LYS95 |
| A | GLY379 |
| A | THR380 |
| A | ASP383 |
| B | ARG122 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 402 |
| Chain | Residue |
| B | LEU174 |
| B | SER176 |
| B | ARG179 |
| A | LEU174 |
| A | SER176 |
| A | ARG179 |
| A | HOH517 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DLY A 403 |
| Chain | Residue |
| A | ARG144 |
| A | THR145 |
| A | ASP146 |
| A | VAL149 |
| A | TYR201 |
| A | ARG295 |
| A | LEU333 |
| A | HOH719 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DGL B 401 |
| Chain | Residue |
| B | THR145 |
| B | ASP146 |
| B | VAL149 |
| B | TYR201 |
| B | MET290 |
| B | HIS292 |
| B | GLN293 |
| B | ILE294 |
| B | ARG295 |
| B | HOH751 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"24722331","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ITS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZ6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
