4NV0
Crystal structure of cytosolic 5'-nucleotidase IIIB (cN-IIIB) bound to 7-methylguanosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008252 | molecular_function | nucleotidase activity |
| A | 0008253 | molecular_function | 5'-nucleotidase activity |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009158 | biological_process | ribonucleoside monophosphate catabolic process |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106411 | molecular_function | XMP 5'-nucleosidase activity |
| A | 1901069 | biological_process | guanosine-containing compound catabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008252 | molecular_function | nucleotidase activity |
| B | 0008253 | molecular_function | 5'-nucleotidase activity |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0009158 | biological_process | ribonucleoside monophosphate catabolic process |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0106411 | molecular_function | XMP 5'-nucleosidase activity |
| B | 1901069 | biological_process | guanosine-containing compound catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PGE A 401 |
| Chain | Residue |
| A | ARG13 |
| B | HOH695 |
| A | ALA33 |
| A | GLU36 |
| A | ARG37 |
| A | ASN40 |
| A | ILE44 |
| A | HOH723 |
| A | HOH768 |
| B | GLU155 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ASP55 |
| A | ASP57 |
| A | ASP245 |
| A | MGF404 |
| A | HOH626 |
| A | HOH627 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MG7 A 403 |
| Chain | Residue |
| A | ASP57 |
| A | PHE75 |
| A | ARG100 |
| A | GLU103 |
| A | TRP120 |
| A | TRP121 |
| A | SER124 |
| A | GLY173 |
| A | HOH515 |
| A | HOH540 |
| A | HOH579 |
| A | HOH586 |
| A | HOH605 |
| A | HOH662 |
| A | HOH776 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MGF A 404 |
| Chain | Residue |
| A | ASP55 |
| A | PHE56 |
| A | ASP57 |
| A | SER171 |
| A | ALA172 |
| A | LYS219 |
| A | MG402 |
| A | HOH523 |
| A | HOH540 |
| A | HOH626 |
| A | HOH627 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | ASP55 |
| B | ASP57 |
| B | ASP245 |
| B | MGF403 |
| B | HOH644 |
| B | HOH645 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MG7 B 402 |
| Chain | Residue |
| B | SER73 |
| B | PHE75 |
| B | ASN79 |
| B | TYR96 |
| B | GLU103 |
| B | TRP120 |
| B | TRP121 |
| B | SER124 |
| B | HOH502 |
| B | HOH521 |
| B | HOH554 |
| B | HOH574 |
| B | HOH639 |
| B | HOH663 |
| B | HOH693 |
| B | HOH719 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MGF B 403 |
| Chain | Residue |
| B | ASP55 |
| B | PHE56 |
| B | ASP57 |
| B | SER171 |
| B | ALA172 |
| B | LYS219 |
| B | MG401 |
| B | HOH502 |
| B | HOH506 |
| B | HOH644 |
| B | HOH645 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:24603684 |
| Chain | Residue | Details |
| A | ASP55 | |
| B | ASP55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:24603684 |
| Chain | Residue | Details |
| A | ASP57 | |
| B | ASP57 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24603684 |
| Chain | Residue | Details |
| A | ASP245 | |
| B | ASP55 | |
| B | ASP57 | |
| B | GLU103 | |
| B | SER124 | |
| B | ASP245 | |
| A | ASP55 | |
| A | ASP57 | |
| A | GLU103 | |
| A | SER124 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9H0P0 |
| Chain | Residue | Details |
| A | SER171 | |
| B | SER171 |
