4NTX
Structure of acid-sensing ion channel in complex with snake toxin and amiloride
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
| B | 0099106 | molecular_function | ion channel regulator activity |
| C | 0004623 | molecular_function | phospholipase A2 activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006644 | biological_process | phospholipid metabolic process |
| C | 0016042 | biological_process | lipid catabolic process |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| C | 0050482 | biological_process | arachidonate secretion |
| C | 0090729 | molecular_function | toxin activity |
| C | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. CYEDPPF |
| Chain | Residue | Details |
| B | CYS7-PHE13 |
| site_id | PS00119 |
| Number of Residues | 11 |
| Details | PA2_ASP Phospholipase A2 aspartic acid active site. VCNCDRTAtLC |
| Chain | Residue | Details |
| C | VAL90-CYS100 |
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR304-CYS324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:22094702 |
| Chain | Residue | Details |
| B | PCA1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 352 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW |
| Chain | Residue | Details |
| A | TYR72-ALA424 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 29 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW |
| Chain | Residue | Details |
| A | TYR425-ASP454 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation => ECO:0000269|PubMed:22842900 |
| Chain | Residue | Details |
| A | GLU80 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Involved in proton-dependent gating => ECO:0000250|UniProtKB:P78348 |
| Chain | Residue | Details |
| A | ASP356 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900, ECO:0007744|PDB:2QTS |
| Chain | Residue | Details |
| A | ASN367 | |
| A | ASN394 |
