Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4NPQ

The resting-state conformation of the GLIC ligand-gated ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902495	cellular_component	transmembrane transporter complex
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0005267	molecular_function	potassium channel activity
F	0005272	molecular_function	sodium channel activity
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006814	biological_process	sodium ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0035725	biological_process	sodium ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0071805	biological_process	potassium ion transmembrane transport
F	1902495	cellular_component	transmembrane transporter complex
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0005267	molecular_function	potassium channel activity
G	0005272	molecular_function	sodium channel activity
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006814	biological_process	sodium ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0035725	biological_process	sodium ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0071805	biological_process	potassium ion transmembrane transport
G	1902495	cellular_component	transmembrane transporter complex
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0005267	molecular_function	potassium channel activity
H	0005272	molecular_function	sodium channel activity
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006814	biological_process	sodium ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0035725	biological_process	sodium ion transmembrane transport
H	0042802	molecular_function	identical protein binding
H	0071805	biological_process	potassium ion transmembrane transport
H	1902495	cellular_component	transmembrane transporter complex
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0005267	molecular_function	potassium channel activity
I	0005272	molecular_function	sodium channel activity
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006814	biological_process	sodium ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0035725	biological_process	sodium ion transmembrane transport
I	0042802	molecular_function	identical protein binding
I	0071805	biological_process	potassium ion transmembrane transport
I	1902495	cellular_component	transmembrane transporter complex
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0005267	molecular_function	potassium channel activity
J	0005272	molecular_function	sodium channel activity
J	0005886	cellular_component	plasma membrane
J	0006811	biological_process	monoatomic ion transport
J	0006814	biological_process	sodium ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0035725	biological_process	sodium ion transmembrane transport
J	0042802	molecular_function	identical protein binding
J	0071805	biological_process	potassium ion transmembrane transport
J	1902495	cellular_component	transmembrane transporter complex
K	0004888	molecular_function	transmembrane signaling receptor activity
K	0005216	molecular_function	monoatomic ion channel activity
K	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
K	0005267	molecular_function	potassium channel activity
K	0005272	molecular_function	sodium channel activity
K	0005886	cellular_component	plasma membrane
K	0006811	biological_process	monoatomic ion transport
K	0006814	biological_process	sodium ion transport
K	0016020	cellular_component	membrane
K	0034220	biological_process	monoatomic ion transmembrane transport
K	0035725	biological_process	sodium ion transmembrane transport
K	0042802	molecular_function	identical protein binding
K	0071805	biological_process	potassium ion transmembrane transport
K	1902495	cellular_component	transmembrane transporter complex
L	0004888	molecular_function	transmembrane signaling receptor activity
L	0005216	molecular_function	monoatomic ion channel activity
L	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
L	0005267	molecular_function	potassium channel activity
L	0005272	molecular_function	sodium channel activity
L	0005886	cellular_component	plasma membrane
L	0006811	biological_process	monoatomic ion transport
L	0006814	biological_process	sodium ion transport
L	0016020	cellular_component	membrane
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0035725	biological_process	sodium ion transmembrane transport
L	0042802	molecular_function	identical protein binding
L	0071805	biological_process	potassium ion transmembrane transport
L	1902495	cellular_component	transmembrane transporter complex
M	0004888	molecular_function	transmembrane signaling receptor activity
M	0005216	molecular_function	monoatomic ion channel activity
M	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
M	0005267	molecular_function	potassium channel activity
M	0005272	molecular_function	sodium channel activity
M	0005886	cellular_component	plasma membrane
M	0006811	biological_process	monoatomic ion transport
M	0006814	biological_process	sodium ion transport
M	0016020	cellular_component	membrane
M	0034220	biological_process	monoatomic ion transmembrane transport
M	0035725	biological_process	sodium ion transmembrane transport
M	0042802	molecular_function	identical protein binding
M	0071805	biological_process	potassium ion transmembrane transport
M	1902495	cellular_component	transmembrane transporter complex
N	0004888	molecular_function	transmembrane signaling receptor activity
N	0005216	molecular_function	monoatomic ion channel activity
N	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
N	0005267	molecular_function	potassium channel activity
N	0005272	molecular_function	sodium channel activity
N	0005886	cellular_component	plasma membrane
N	0006811	biological_process	monoatomic ion transport
N	0006814	biological_process	sodium ion transport
N	0016020	cellular_component	membrane
N	0034220	biological_process	monoatomic ion transmembrane transport
N	0035725	biological_process	sodium ion transmembrane transport
N	0042802	molecular_function	identical protein binding
N	0071805	biological_process	potassium ion transmembrane transport
N	1902495	cellular_component	transmembrane transporter complex
O	0004888	molecular_function	transmembrane signaling receptor activity
O	0005216	molecular_function	monoatomic ion channel activity
O	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
O	0005267	molecular_function	potassium channel activity
O	0005272	molecular_function	sodium channel activity
O	0005886	cellular_component	plasma membrane
O	0006811	biological_process	monoatomic ion transport
O	0006814	biological_process	sodium ion transport
O	0016020	cellular_component	membrane
O	0034220	biological_process	monoatomic ion transmembrane transport
O	0035725	biological_process	sodium ion transmembrane transport
O	0042802	molecular_function	identical protein binding
O	0071805	biological_process	potassium ion transmembrane transport
O	1902495	cellular_component	transmembrane transporter complex
P	0004888	molecular_function	transmembrane signaling receptor activity
P	0005216	molecular_function	monoatomic ion channel activity
P	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
P	0005267	molecular_function	potassium channel activity
P	0005272	molecular_function	sodium channel activity
P	0005886	cellular_component	plasma membrane
P	0006811	biological_process	monoatomic ion transport
P	0006814	biological_process	sodium ion transport
P	0016020	cellular_component	membrane
P	0034220	biological_process	monoatomic ion transmembrane transport
P	0035725	biological_process	sodium ion transmembrane transport
P	0042802	molecular_function	identical protein binding
P	0071805	biological_process	potassium ion transmembrane transport
P	1902495	cellular_component	transmembrane transporter complex
Q	0004888	molecular_function	transmembrane signaling receptor activity
Q	0005216	molecular_function	monoatomic ion channel activity
Q	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
Q	0005267	molecular_function	potassium channel activity
Q	0005272	molecular_function	sodium channel activity
Q	0005886	cellular_component	plasma membrane
Q	0006811	biological_process	monoatomic ion transport
Q	0006814	biological_process	sodium ion transport
Q	0016020	cellular_component	membrane
Q	0034220	biological_process	monoatomic ion transmembrane transport
Q	0035725	biological_process	sodium ion transmembrane transport
Q	0042802	molecular_function	identical protein binding
Q	0071805	biological_process	potassium ion transmembrane transport
Q	1902495	cellular_component	transmembrane transporter complex
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0005216	molecular_function	monoatomic ion channel activity
R	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
R	0005267	molecular_function	potassium channel activity
R	0005272	molecular_function	sodium channel activity
R	0005886	cellular_component	plasma membrane
R	0006811	biological_process	monoatomic ion transport
R	0006814	biological_process	sodium ion transport
R	0016020	cellular_component	membrane
R	0034220	biological_process	monoatomic ion transmembrane transport
R	0035725	biological_process	sodium ion transmembrane transport
R	0042802	molecular_function	identical protein binding
R	0071805	biological_process	potassium ion transmembrane transport
R	1902495	cellular_component	transmembrane transporter complex
S	0004888	molecular_function	transmembrane signaling receptor activity
S	0005216	molecular_function	monoatomic ion channel activity
S	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
S	0005267	molecular_function	potassium channel activity
S	0005272	molecular_function	sodium channel activity
S	0005886	cellular_component	plasma membrane
S	0006811	biological_process	monoatomic ion transport
S	0006814	biological_process	sodium ion transport
S	0016020	cellular_component	membrane
S	0034220	biological_process	monoatomic ion transmembrane transport
S	0035725	biological_process	sodium ion transmembrane transport
S	0042802	molecular_function	identical protein binding
S	0071805	biological_process	potassium ion transmembrane transport
S	1902495	cellular_component	transmembrane transporter complex
T	0004888	molecular_function	transmembrane signaling receptor activity
T	0005216	molecular_function	monoatomic ion channel activity
T	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
T	0005267	molecular_function	potassium channel activity
T	0005272	molecular_function	sodium channel activity
T	0005886	cellular_component	plasma membrane
T	0006811	biological_process	monoatomic ion transport
T	0006814	biological_process	sodium ion transport
T	0016020	cellular_component	membrane
T	0034220	biological_process	monoatomic ion transmembrane transport
T	0035725	biological_process	sodium ion transmembrane transport
T	0042802	molecular_function	identical protein binding
T	0071805	biological_process	potassium ion transmembrane transport
T	1902495	cellular_component	transmembrane transporter complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3960
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
F	GLN2-GLN193
F	ASN245-MET252
G	GLN2-GLN193
G	ASN245-MET252
H	GLN2-GLN193
H	ASN245-MET252
I	GLN2-GLN193
I	ASN245-MET252
J	GLN2-GLN193
A	ASN245-MET252
J	ASN245-MET252
K	GLN2-GLN193
K	ASN245-MET252
L	GLN2-GLN193
L	ASN245-MET252
M	GLN2-GLN193
M	ASN245-MET252
N	GLN2-GLN193
N	ASN245-MET252
O	GLN2-GLN193
B	GLN2-GLN193
O	ASN245-MET252
P	GLN2-GLN193
P	ASN245-MET252
Q	GLN2-GLN193
Q	ASN245-MET252
R	GLN2-GLN193
R	ASN245-MET252
S	GLN2-GLN193
S	ASN245-MET252
T	GLN2-GLN193
B	ASN245-MET252
T	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	2120
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
F	TYR194-PHE216
F	SER220-THR244
F	THR253-VAL281
F	PRO285-PHE317
G	TYR194-PHE216
G	SER220-THR244
G	THR253-VAL281
G	PRO285-PHE317
H	TYR194-PHE216
A	THR253-VAL281
H	SER220-THR244
H	THR253-VAL281
H	PRO285-PHE317
I	TYR194-PHE216
I	SER220-THR244
I	THR253-VAL281
I	PRO285-PHE317
J	TYR194-PHE216
J	SER220-THR244
J	THR253-VAL281
A	PRO285-PHE317
J	PRO285-PHE317
K	TYR194-PHE216
K	SER220-THR244
K	THR253-VAL281
K	PRO285-PHE317
L	TYR194-PHE216
L	SER220-THR244
L	THR253-VAL281
L	PRO285-PHE317
M	TYR194-PHE216
B	TYR194-PHE216
M	SER220-THR244
M	THR253-VAL281
M	PRO285-PHE317
N	TYR194-PHE216
N	SER220-THR244
N	THR253-VAL281
N	PRO285-PHE317
O	TYR194-PHE216
O	SER220-THR244
O	THR253-VAL281
B	SER220-THR244
O	PRO285-PHE317
P	TYR194-PHE216
P	SER220-THR244
P	THR253-VAL281
P	PRO285-PHE317
Q	TYR194-PHE216
Q	SER220-THR244
Q	THR253-VAL281
Q	PRO285-PHE317
R	TYR194-PHE216
B	THR253-VAL281
R	SER220-THR244
R	THR253-VAL281
R	PRO285-PHE317
S	TYR194-PHE216
S	SER220-THR244
S	THR253-VAL281
S	PRO285-PHE317
T	TYR194-PHE216
T	SER220-THR244
T	THR253-VAL281
B	PRO285-PHE317
T	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	80
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
F	TRP217-THR219
F	GLU282-GLN284
G	TRP217-THR219
G	GLU282-GLN284
H	TRP217-THR219
H	GLU282-GLN284
I	TRP217-THR219
I	GLU282-GLN284
J	TRP217-THR219
A	GLU282-GLN284
J	GLU282-GLN284
K	TRP217-THR219
K	GLU282-GLN284
L	TRP217-THR219
L	GLU282-GLN284
M	TRP217-THR219
M	GLU282-GLN284
N	TRP217-THR219
N	GLU282-GLN284
O	TRP217-THR219
B	TRP217-THR219
O	GLU282-GLN284
P	TRP217-THR219
P	GLU282-GLN284
Q	TRP217-THR219
Q	GLU282-GLN284
R	TRP217-THR219
R	GLU282-GLN284
S	TRP217-THR219
S	GLU282-GLN284
T	TRP217-THR219
B	GLU282-GLN284
T	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)