4NL8

PriA Helicase Bound to SSB C-terminal Tail Peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0006302	biological_process	double-strand break repair
A	0006310	biological_process	DNA recombination
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0046872	molecular_function	metal ion binding
A	1990077	cellular_component	primosome complex
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
B	0006269	biological_process	DNA replication, synthesis of primer
B	0006270	biological_process	DNA replication initiation
B	0006302	biological_process	double-strand break repair
B	0006310	biological_process	DNA recombination
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0043138	molecular_function	3'-5' DNA helicase activity
B	0046872	molecular_function	metal ion binding
B	1990077	cellular_component	primosome complex
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0006260	biological_process	DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0006302	biological_process	double-strand break repair
E	0006310	biological_process	DNA recombination
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0043138	molecular_function	3'-5' DNA helicase activity
E	0046872	molecular_function	metal ion binding
E	1990077	cellular_component	primosome complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 801

Chain	Residue
A	CYS435
A	CYS438
A	CYS475
A	CYS478

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 802

Chain	Residue
A	CYS444
A	CYS447
A	CYS462
A	CYS465

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 801

Chain	Residue
B	CYS438
B	CYS475
B	CYS478
B	CYS435

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 802

Chain	Residue
B	CYS444
B	CYS447
B	CYS462
B	CYS465

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 801

Chain	Residue
E	CYS444
E	CYS447
E	CYS462
E	CYS465

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 802

Chain	Residue
E	CYS435
E	CYS438
E	CYS475
E	CYS478

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	498
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	525
Details	Region: {"description":"Helicase lobe 1","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	129
Details	Region: {"description":"Helicase lobe 2, N-terminus","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	162
Details	Region: {"description":"CRR","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Motif: {"description":"DEAH box","evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Motif: {"description":"Aromatic-rich loop (ARL)","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DGD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---