4NKQ

Structure of a Cytokine Receptor Complex

Replaces:  3CXE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004896	molecular_function	cytokine receptor activity
A	0016020	cellular_component	membrane
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0001821	biological_process	histamine secretion
C	0005125	molecular_function	cytokine activity
C	0005129	molecular_function	granulocyte macrophage colony-stimulating factor receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0007165	biological_process	signal transduction
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009966	biological_process	regulation of signal transduction
C	0010628	biological_process	positive regulation of gene expression
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0030099	biological_process	myeloid cell differentiation
C	0030225	biological_process	macrophage differentiation
C	0030335	biological_process	positive regulation of cell migration
C	0032747	biological_process	positive regulation of interleukin-23 production
C	0034021	biological_process	response to silicon dioxide
C	0034405	biological_process	response to fluid shear stress
C	0038157	biological_process	granulocyte-macrophage colony-stimulating factor signaling pathway
C	0042045	biological_process	epithelial fluid transport
C	0043011	biological_process	myeloid dendritic cell differentiation
C	0045187	biological_process	regulation of circadian sleep/wake cycle, sleep
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0050793	biological_process	regulation of developmental process
C	0070665	biological_process	positive regulation of leukocyte proliferation
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071803	biological_process	positive regulation of podosome assembly
C	0097011	biological_process	cellular response to granulocyte macrophage colony-stimulating factor stimulus
C	0097028	biological_process	dendritic cell differentiation
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00702
Number of Residues	9
Details	GM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC

Chain	Residue	Details
C	CYS88-CYS96

---

site_id	PS01355
Number of Residues	33
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LepstrywarVRvrtsrtgyngi.........WSeWSearsW

Chain	Residue	Details
A	LEU402-TRP434

---

site_id	PS01356
Number of Residues	32
Details	HEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. MnCtWarGptaprDvqYfLyirnskrrreir..C

Chain	Residue	Details
B	MET115-CYS146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	97
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16754968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18692472","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18692472","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---