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Crystal structure of Trypanothione Reductase from Trypanosoma cruzi in complex with inhibitor EP127 (5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE)

Functional Information from GO Data
ChainGOidnamespacecontents
A0015036molecular_functiondisulfide oxidoreductase activity
A0016491molecular_functionoxidoreductase activity
A0016668molecular_functionoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A0045454biological_processcell redox homeostasis
A0050660molecular_functionflavin adenine dinucleotide binding
Functional Information from PDB Data
site_idAC1
Number of Residues31
DetailsBINDING SITE FOR RESIDUE FAD A 501
ChainResidue
AILE11
ASER47
AGLY51
ATHR52
ACYS53
ACYS58
ALYS61
AGLY128
AALA160
ASER161
AGLY162
AGLY12
ASER179
AILE200
AARG288
AARG291
ALEU295
AGLY326
AASP327
AMET333
ALEU334
ATHR335
AALA13
APRO336
AHIS461
AGLY14
ASER15
AGLY16
AILE35
AASP36
AVAL37

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE 2JR A 502
ChainResidue
AGLU19
ATRP22
ASER110
AMET114

Functional Information from PROSITE/UniProt
site_idPS00076
Number of Residues11
DetailsPYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP
ChainResidueDetails
AGLY50-PRO60

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PDB entries from 2024-07-24

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