4ND3
Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (l-lactic acid) and cofactor (b-nicotinamide adenine dinucleotide)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NAD A 401 |
Chain | Residue |
A | GLY30 |
A | ASN140 |
A | MET163 |
A | LEU167 |
A | HIS195 |
A | GLU223 |
A | ALA246 |
A | PRO250 |
A | 2OP402 |
A | HOH602 |
A | HOH603 |
A | GLN31 |
A | HOH611 |
A | HOH620 |
A | HOH631 |
A | HOH637 |
A | HOH652 |
A | HOH668 |
A | ILE32 |
A | ASP53 |
A | THR97 |
A | ALA98 |
A | SER99 |
A | ILE119 |
A | ILE138 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 2OP A 402 |
Chain | Residue |
A | ARG109 |
A | ASN140 |
A | ARG171 |
A | HIS195 |
A | TRP236 |
A | NAD401 |
A | HOH606 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 403 |
Chain | Residue |
A | PRO201 |
A | THR203 |
A | GLU311 |
A | HOH688 |
site_id | AC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 404 |
Chain | Residue |
A | PRO141 |
A | LEU142 |
A | ASP143 |
A | VAL144 |
A | GLY194 |
A | HIS195 |
A | GLU321 |
A | HOH680 |
site_id | AC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAD B 401 |
Chain | Residue |
B | GLY30 |
B | GLN31 |
B | ILE32 |
B | ASP53 |
B | ILE54 |
B | ALA55 |
B | THR97 |
B | ALA98 |
B | SER99 |
B | ILE119 |
B | ILE138 |
B | ASN140 |
B | MET163 |
B | LEU167 |
B | HIS195 |
B | ALA246 |
B | HOH514 |
B | HOH517 |
B | HOH524 |
B | HOH529 |
B | HOH580 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 402 |
Chain | Residue |
B | PRO201 |
B | THR203 |
B | GLU311 |
B | LEU314 |
B | HOH558 |
Functional Information from PROSITE/UniProt
site_id | PS00065 |
Number of Residues | 29 |
Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. IAVIGsGQIGgniayivgkdnladVVlFD |
Chain | Residue | Details |
A | ILE24-ASP53 |
site_id | PS00659 |
Number of Residues | 10 |
Details | GLYCOSYL_HYDROL_F5 Glycosyl hydrolases family 5 signature. LLGESINEVN |
Chain | Residue | Details |
A | LEU314-ASN323 |