4N99
E. coli sliding clamp in complex with 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044787 | biological_process | bacterial-type DNA replication |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006261 | biological_process | DNA-templated DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| B | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| B | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044787 | biological_process | bacterial-type DNA replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 2J1 A 401 |
| Chain | Residue |
| A | ARG152 |
| A | GLY174 |
| A | PRO242 |
| A | VAL247 |
| A | SER346 |
| A | MET362 |
| A | HOH523 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 402 |
| Chain | Residue |
| A | GLU287 |
| A | GLN289 |
| A | PG4416 |
| A | ARG103 |
| A | SER286 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 403 |
| Chain | Residue |
| A | TRP122 |
| A | GLN217 |
| A | ARG224 |
| A | HOH520 |
| B | ALA38 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 404 |
| Chain | Residue |
| A | ALA268 |
| A | ARG279 |
| A | LEU325 |
| B | ASP77 |
| B | ARG80 |
| B | GLY81 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 405 |
| Chain | Residue |
| A | GLN36 |
| A | SER43 |
| A | ARG56 |
| A | ILE231 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 406 |
| Chain | Residue |
| A | ARG80 |
| A | GLY81 |
| A | PRO83 |
| B | GLN265 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 407 |
| Chain | Residue |
| A | ALA58 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 408 |
| Chain | Residue |
| A | SER181 |
| A | GLN348 |
| A | GLN355 |
| A | SER356 |
| A | HOH548 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 409 |
| Chain | Residue |
| A | GLU316 |
| A | LEU366 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 410 |
| Chain | Residue |
| A | PRO83 |
| A | GLY102 |
| A | ARG103 |
| A | SER104 |
| A | PG4415 |
| A | HOH583 |
| B | ARG269 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 411 |
| Chain | Residue |
| A | ASP229 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG A 412 |
| Chain | Residue |
| A | LEU262 |
| A | ALA266 |
| A | ARG269 |
| A | ILE305 |
| A | LEU306 |
| A | ASP307 |
| A | HOH565 |
| B | PG4401 |
| B | PEG415 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 413 |
| Chain | Residue |
| A | GLU64 |
| B | PRO189 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 414 |
| Chain | Residue |
| A | GLN299 |
| A | GLU301 |
| B | SER107 |
| B | TYR284 |
| B | PG4412 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 415 |
| Chain | Residue |
| A | PRO112 |
| A | ALA114 |
| A | ASP115 |
| A | PG4410 |
| B | ILE305 |
| B | LEU306 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 416 |
| Chain | Residue |
| A | ARG105 |
| A | GLN289 |
| A | PEG402 |
| A | HOH596 |
| B | ILE305 |
| B | PG4412 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 417 |
| Chain | Residue |
| A | GLU314 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 418 |
| Chain | Residue |
| A | ARG137 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 401 |
| Chain | Residue |
| A | LEU262 |
| A | ARG269 |
| A | PEG412 |
| A | HOH599 |
| B | PRO83 |
| B | PEG415 |
| B | HOH513 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 402 |
| Chain | Residue |
| B | SER18 |
| B | ARG73 |
| B | PHE76 |
| B | ARG80 |
| B | PEG416 |
| B | HOH551 |
| B | HOH576 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 403 |
| Chain | Residue |
| B | GLU52 |
| B | ARG56 |
| B | ASN118 |
| B | LEU119 |
| B | HOH555 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 B 404 |
| Chain | Residue |
| B | LEU82 |
| B | HOH580 |
| A | ARG152 |
| B | ARG7 |
| B | ARG80 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG B 405 |
| Chain | Residue |
| A | ALA38 |
| B | ARG215 |
| B | GLN217 |
| B | ARG224 |
| B | HIS226 |
| B | ILE231 |
| B | PEG413 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 406 |
| Chain | Residue |
| B | LYS264 |
| B | GLN265 |
| B | ALA268 |
| B | ALA271 |
| B | ARG279 |
| B | LEU325 |
| B | ASN329 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 407 |
| Chain | Residue |
| B | ASP229 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG B 408 |
| Chain | Residue |
| B | GLU50 |
| B | TYR153 |
| B | ASN156 |
| B | GLY157 |
| B | PRO196 |
| B | ARG197 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 410 |
| Chain | Residue |
| A | GLU276 |
| B | ARG73 |
| B | LYS74 |
| B | PEG416 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 411 |
| Chain | Residue |
| A | GLN123 |
| A | GLU125 |
| B | ALA67 |
| B | GLY94 |
| B | PRO112 |
| B | ALA113 |
| B | ALA114 |
| site_id | DC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PG4 B 412 |
| Chain | Residue |
| A | GLU301 |
| A | GLU303 |
| A | PEG414 |
| A | PG4416 |
| B | ARG105 |
| B | SER107 |
| B | TYR284 |
| B | SER286 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 413 |
| Chain | Residue |
| B | ASP121 |
| B | TRP122 |
| B | SER124 |
| B | ARG224 |
| B | PEG405 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 414 |
| Chain | Residue |
| B | SER181 |
| B | GLN348 |
| B | GLN355 |
| B | SER356 |
| B | HOH603 |
| site_id | DC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PEG B 415 |
| Chain | Residue |
| A | ARG269 |
| A | ILE305 |
| A | PEG412 |
| B | LEU82 |
| B | PRO83 |
| B | ALA86 |
| B | SER101 |
| B | ARG103 |
| B | SER104 |
| B | PG4401 |
| B | HOH600 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 416 |
| Chain | Residue |
| B | PRO25 |
| B | ARG73 |
| B | PG4402 |
| B | PEG410 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 417 |
| Chain | Residue |
| B | GLU93 |
| B | SER107 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | Region: {"description":"3","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 114 |
| Details | Region: {"description":"2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
