Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4N78

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000902	biological_process	cell morphogenesis
A	0001726	cellular_component	ruffle
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006417	biological_process	regulation of translation
A	0007399	biological_process	nervous system development
A	0007411	biological_process	axon guidance
A	0008360	biological_process	regulation of cell shape
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0016601	biological_process	Rac protein signal transduction
A	0017148	biological_process	negative regulation of translation
A	0030027	cellular_component	lamellipodium
A	0030032	biological_process	lamellipodium assembly
A	0030154	biological_process	cell differentiation
A	0030371	molecular_function	translation repressor activity
A	0030833	biological_process	regulation of actin filament polymerization
A	0031175	biological_process	neuron projection development
A	0031209	cellular_component	SCAR complex
A	0031252	cellular_component	cell leading edge
A	0031267	molecular_function	small GTPase binding
A	0031529	biological_process	ruffle organization
A	0034774	cellular_component	secretory granule lumen
A	0035580	cellular_component	specific granule lumen
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048675	biological_process	axon extension
A	0050890	biological_process	cognition
A	0051015	molecular_function	actin filament binding
A	0051388	biological_process	positive regulation of neurotrophin TRK receptor signaling pathway
A	0060076	cellular_component	excitatory synapse
A	0070062	cellular_component	extracellular exosome
A	0097484	biological_process	dendrite extension
A	0098794	cellular_component	postsynapse
A	0099578	biological_process	regulation of translation at postsynapse, modulating synaptic transmission
A	1904724	cellular_component	tertiary granule lumen
A	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
A	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation
B	0000902	biological_process	cell morphogenesis
B	0001726	cellular_component	ruffle
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006915	biological_process	apoptotic process
B	0007417	biological_process	central nervous system development
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0016477	biological_process	cell migration
B	0016601	biological_process	Rac protein signal transduction
B	0030027	cellular_component	lamellipodium
B	0030031	biological_process	cell projection assembly
B	0030838	biological_process	positive regulation of actin filament polymerization
B	0030866	biological_process	cortical actin cytoskeleton organization
B	0031209	cellular_component	SCAR complex
B	0031258	cellular_component	lamellipodium membrane
B	0031267	molecular_function	small GTPase binding
B	0031941	cellular_component	filamentous actin
B	0048812	biological_process	neuron projection morphogenesis
B	0070062	cellular_component	extracellular exosome
B	0098794	cellular_component	postsynapse
B	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation
D	0003779	molecular_function	actin binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005925	cellular_component	focal adhesion
D	0006898	biological_process	receptor-mediated endocytosis
D	0007005	biological_process	mitochondrion organization
D	0015629	cellular_component	actin cytoskeleton
D	0016601	biological_process	Rac protein signal transduction
D	0030027	cellular_component	lamellipodium
D	0030036	biological_process	actin cytoskeleton organization
D	0030041	biological_process	actin filament polymerization
D	0031175	biological_process	neuron projection development
D	0031209	cellular_component	SCAR complex
D	0031267	molecular_function	small GTPase binding
D	0032839	cellular_component	dendrite cytoplasm
D	0032991	cellular_component	protein-containing complex
D	0034237	molecular_function	protein kinase A regulatory subunit binding
D	0045202	cellular_component	synapse
D	0051018	molecular_function	protein kinase A binding
D	0051388	biological_process	positive regulation of neurotrophin TRK receptor signaling pathway
D	0065003	biological_process	protein-containing complex assembly
D	0071933	molecular_function	Arp2/3 complex binding
D	0072673	biological_process	lamellipodium morphogenesis
D	0097484	biological_process	dendrite extension
D	0098794	cellular_component	postsynapse
D	0098885	biological_process	modification of postsynaptic actin cytoskeleton
D	0098939	biological_process	dendritic transport of mitochondrion
D	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
D	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0007015	biological_process	actin filament organization
E	0008064	biological_process	regulation of actin polymerization or depolymerization
E	0010592	biological_process	positive regulation of lamellipodium assembly
E	0016601	biological_process	Rac protein signal transduction
E	0030027	cellular_component	lamellipodium
E	0031209	cellular_component	SCAR complex
E	0031267	molecular_function	small GTPase binding
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0042802	molecular_function	identical protein binding
E	0044877	molecular_function	protein-containing complex binding
E	0048870	biological_process	cell motility
E	0070062	cellular_component	extracellular exosome
E	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation
F	0000423	biological_process	mitophagy
F	0001764	biological_process	neuron migration
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005912	cellular_component	adherens junction
F	0007010	biological_process	cytoskeleton organization
F	0007399	biological_process	nervous system development
F	0008093	molecular_function	cytoskeletal anchor activity
F	0008154	biological_process	actin polymerization or depolymerization
F	0010592	biological_process	positive regulation of lamellipodium assembly
F	0016477	biological_process	cell migration
F	0016601	biological_process	Rac protein signal transduction
F	0017124	molecular_function	SH3 domain binding
F	0018108	biological_process	peptidyl-tyrosine phosphorylation
F	0019900	molecular_function	kinase binding
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0031209	cellular_component	SCAR complex
F	0031267	molecular_function	small GTPase binding
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032433	cellular_component	filopodium tip
F	0035591	molecular_function	signaling adaptor activity
F	0042802	molecular_function	identical protein binding
F	0043197	cellular_component	dendritic spine
F	0048858	biological_process	cell projection morphogenesis
F	0061001	biological_process	regulation of dendritic spine morphogenesis
F	0070309	biological_process	lens fiber cell morphogenesis
F	0098858	cellular_component	actin-based cell projection
F	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1301

Chain	Residue
A	HOH1589

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1302

Chain	Residue
A	LYS656
A	ALA658
A	PRO742
A	SER743
A	ASN744
A	HOH1549

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1303

Chain	Residue
A	LYS1202
A	ARG1209
A	HOH1617
A	GLN1187
A	LYS1188

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1304

Chain	Residue
A	GLN77
A	PHE308
A	GLY309
A	GLN620
A	TYR677

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1305

Chain	Residue
A	TYR79
A	LYS121

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1306

Chain	Residue
A	THR769
A	THR817
A	HOH1449
A	HOH1494
A	HOH1559
A	HOH1600
A	HOH1628
E	ARG59

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1201

Chain	Residue
B	ARG715
B	LYS718
B	GOL1208
B	HOH1435

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1202

Chain	Residue
B	ARG340
B	ARG343
B	PHE400
B	HOH1335

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 1203

Chain	Residue
B	ASP926

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1204

Chain	Residue
B	ARG744
B	SER834
B	ARG837
B	GLU841

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1205

Chain	Residue
B	PHE481
B	ASP482
B	ARG484
B	ASP527
B	SER528
B	GLU531

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1206

Chain	Residue
B	LEU793
B	GLU794
B	ARG798
B	SER801
B	HIS858

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1207

Chain	Residue
B	ASP901
B	LEU1010
B	ASN1013
B	ASN1027

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 1208

Chain	Residue
B	LYS608
B	ARG611
B	CL1201

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 1209

Chain	Residue
A	GLU61
A	THR64
A	VAL65
A	SER68
B	VAL451
B	SER503
B	LEU504
B	GLY505
B	ASP508
B	HIS509

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1210

Chain	Residue
B	GLN921
B	CYS969
B	ASP972
B	HOH1327

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1211

Chain	Residue
B	ARG420
B	MET695
B	VAL696
B	HOH1490

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1212

Chain	Residue
B	ARG30
B	ASN33
B	ILE34
B	LEU92
B	CYS584
B	GLU586

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL F 601

Chain	Residue
F	HIS122
F	LYS123

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL F 602

Chain	Residue
B	GLU582
B	LEU583
D	GLN82
F	ARG135
F	TYR136
F	ILE137
F	LYS139

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	17
Details	Domain: {"description":"WH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00406","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	31
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	62
Details	Domain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62484","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)