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4N78

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

Functional Information from GO Data
ChainGOidnamespacecontents
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000902biological_processcell morphogenesis
A0001726cellular_componentruffle
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006417biological_processregulation of translation
A0007399biological_processnervous system development
A0007411biological_processaxon guidance
A0008360biological_processregulation of cell shape
A0010592biological_processpositive regulation of lamellipodium assembly
A0016601biological_processRac protein signal transduction
A0017148biological_processnegative regulation of translation
A0030027cellular_componentlamellipodium
A0030032biological_processlamellipodium assembly
A0030154biological_processcell differentiation
A0030371molecular_functiontranslation repressor activity
A0030833biological_processregulation of actin filament polymerization
A0031175biological_processneuron projection development
A0031209cellular_componentSCAR complex
A0031252cellular_componentcell leading edge
A0031267molecular_functionsmall GTPase binding
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0032433cellular_componentfilopodium tip
A0032869biological_processcellular response to insulin stimulus
A0034774cellular_componentsecretory granule lumen
A0035580cellular_componentspecific granule lumen
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043195cellular_componentterminal bouton
A0043197cellular_componentdendritic spine
A0044294cellular_componentdendritic growth cone
A0044295cellular_componentaxonal growth cone
A0045202cellular_componentsynapse
A0045773biological_processpositive regulation of axon extension
A0048471cellular_componentperinuclear region of cytoplasm
A0048675biological_processaxon extension
A0050772biological_processpositive regulation of axonogenesis
A0050890biological_processcognition
A0051015molecular_functionactin filament binding
A0051388biological_processpositive regulation of neurotrophin TRK receptor signaling pathway
A0051602biological_processresponse to electrical stimulus
A0060076cellular_componentexcitatory synapse
A0070062cellular_componentextracellular exosome
A0090724cellular_componentcentral region of growth cone
A0090725cellular_componentperipheral region of growth cone
A0097484biological_processdendrite extension
A0098794cellular_componentpostsynapse
A0099563biological_processmodification of synaptic structure
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A1900006biological_processpositive regulation of dendrite development
A1900029biological_processpositive regulation of ruffle assembly
A1903422biological_processnegative regulation of synaptic vesicle recycling
A1904724cellular_componenttertiary granule lumen
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
B0000902biological_processcell morphogenesis
B0001726cellular_componentruffle
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006915biological_processapoptotic process
B0007417biological_processcentral nervous system development
B0010592biological_processpositive regulation of lamellipodium assembly
B0016477biological_processcell migration
B0016601biological_processRac protein signal transduction
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030838biological_processpositive regulation of actin filament polymerization
B0030866biological_processcortical actin cytoskeleton organization
B0031209cellular_componentSCAR complex
B0031258cellular_componentlamellipodium membrane
B0031267molecular_functionsmall GTPase binding
B0031941cellular_componentfilamentous actin
B0042995cellular_componentcell projection
B0048812biological_processneuron projection morphogenesis
B0070062cellular_componentextracellular exosome
B2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
D0003779molecular_functionactin binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005925cellular_componentfocal adhesion
D0006898biological_processreceptor-mediated endocytosis
D0007005biological_processmitochondrion organization
D0015629cellular_componentactin cytoskeleton
D0016601biological_processRac protein signal transduction
D0030027cellular_componentlamellipodium
D0030036biological_processactin cytoskeleton organization
D0030041biological_processactin filament polymerization
D0031175biological_processneuron projection development
D0031209cellular_componentSCAR complex
D0031267molecular_functionsmall GTPase binding
D0032991cellular_componentprotein-containing complex
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0045202cellular_componentsynapse
D0051018molecular_functionprotein kinase A binding
D0051388biological_processpositive regulation of neurotrophin TRK receptor signaling pathway
D0065003biological_processprotein-containing complex assembly
D0070161cellular_componentanchoring junction
D0071933molecular_functionArp2/3 complex binding
D0072673biological_processlamellipodium morphogenesis
D0097484biological_processdendrite extension
D0098794cellular_componentpostsynapse
D0098885biological_processmodification of postsynaptic actin cytoskeleton
D1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
D2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
E0001701biological_processin utero embryonic development
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0007015biological_processactin filament organization
E0008064biological_processregulation of actin polymerization or depolymerization
E0010592biological_processpositive regulation of lamellipodium assembly
E0016601biological_processRac protein signal transduction
E0030027cellular_componentlamellipodium
E0030036biological_processactin cytoskeleton organization
E0031209cellular_componentSCAR complex
E0031267molecular_functionsmall GTPase binding
E0031334biological_processpositive regulation of protein-containing complex assembly
E0042802molecular_functionidentical protein binding
E0044877molecular_functionprotein-containing complex binding
E0048144biological_processfibroblast proliferation
E0048146biological_processpositive regulation of fibroblast proliferation
E0048870biological_processcell motility
E0070062cellular_componentextracellular exosome
E2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
F0000423biological_processmitophagy
F0001764biological_processneuron migration
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005912cellular_componentadherens junction
F0007010biological_processcytoskeleton organization
F0007399biological_processnervous system development
F0008093molecular_functioncytoskeletal anchor activity
F0008154biological_processactin polymerization or depolymerization
F0010592biological_processpositive regulation of lamellipodium assembly
F0016477biological_processcell migration
F0016601biological_processRac protein signal transduction
F0017124molecular_functionSH3 domain binding
F0018108biological_processpeptidyl-tyrosine phosphorylation
F0019900molecular_functionkinase binding
F0030027cellular_componentlamellipodium
F0030175cellular_componentfilopodium
F0031209cellular_componentSCAR complex
F0031267molecular_functionsmall GTPase binding
F0031625molecular_functionubiquitin protein ligase binding
F0032433cellular_componentfilopodium tip
F0035591molecular_functionsignaling adaptor activity
F0042802molecular_functionidentical protein binding
F0042995cellular_componentcell projection
F0043197cellular_componentdendritic spine
F0061001biological_processregulation of dendritic spine morphogenesis
F0070064molecular_functionproline-rich region binding
F0070161cellular_componentanchoring junction
F0070309biological_processlens fiber cell morphogenesis
F0098858cellular_componentactin-based cell projection
F2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 1301
ChainResidue
AHOH1589

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1302
ChainResidue
ALYS656
AALA658
APRO742
ASER743
AASN744
AHOH1549

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 1303
ChainResidue
ALYS1202
AARG1209
AHOH1617
AGLN1187
ALYS1188

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 1304
ChainResidue
AGLN77
APHE308
AGLY309
AGLN620
ATYR677

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 1305
ChainResidue
ATYR79
ALYS121

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 1306
ChainResidue
ATHR769
ATHR817
AHOH1449
AHOH1494
AHOH1559
AHOH1600
AHOH1628
EARG59

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 1201
ChainResidue
BARG715
BLYS718
BGOL1208
BHOH1435

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 1202
ChainResidue
BARG340
BARG343
BPHE400
BHOH1335

site_idAC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1203
ChainResidue
BASP926

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 1204
ChainResidue
BARG744
BSER834
BARG837
BGLU841

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1205
ChainResidue
BPHE481
BASP482
BARG484
BASP527
BSER528
BGLU531

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 1206
ChainResidue
BLEU793
BGLU794
BARG798
BSER801
BHIS858

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 1207
ChainResidue
BASP901
BLEU1010
BASN1013
BASN1027

site_idBC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 1208
ChainResidue
BLYS608
BARG611
BCL1201

site_idBC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL B 1209
ChainResidue
AGLU61
ATHR64
AVAL65
ASER68
BVAL451
BSER503
BLEU504
BGLY505
BASP508
BHIS509

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 1210
ChainResidue
BGLN921
BCYS969
BASP972
BHOH1327

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 1211
ChainResidue
BARG420
BMET695
BVAL696
BHOH1490

site_idBC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1212
ChainResidue
BARG30
BASN33
BILE34
BLEU92
BCYS584
BGLU586

site_idCC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL F 601
ChainResidue
FHIS122
FLYS123

site_idCC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL F 602
ChainResidue
BGLU582
BLEU583
DGLN82
FARG135
FTYR136
FILE137
FLYS139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62484
ChainResidueDetails
FSER40

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER183

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER227

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62484
ChainResidueDetails
FTHR361

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER368

227344

PDB entries from 2024-11-13

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