Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4N6H

1.8 A Structure of the human delta opioid 7TM receptor (PSI Community Target)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004985	molecular_function	G protein-coupled opioid receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0038046	molecular_function	G protein-coupled enkephalin receptor activity
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 1201

Chain	Residue
A	PRO115
A	PHE116
A	GLU1081
A	OLA1217

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLA A 1202

Chain	Residue
A	SER100
A	OLC1212

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OLA A 1203

Chain	Residue
A	ASP288

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 1204

Chain	Residue
A	ASP290
A	OLA1210
A	ILE279
A	ILE289

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 1205

Chain	Residue
A	TYR233
A	ARG261
A	OLA1215

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLA A 1206

Chain	Residue
A	TYR87
A	ASP145
A	PHE159
A	THR161
A	OLA1209
A	HOH1365

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLC A 1207

Chain	Residue
A	PHE137
A	MET141
A	CYS171
A	ILE172

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLC A 1208

Chain	Residue
A	VAL185
A	GLN201

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 1209

Chain	Residue
A	ALA54
A	LEU55
A	OLA1206
A	PGE1214

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 1210

Chain	Residue
A	ASP293
A	LEU295
A	VAL296
A	OLA1204

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OLA A 1211

Chain	Residue
A	ALA47

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLC A 1212

Chain	Residue
A	GLU118
A	LYS166
A	OLA1202
A	OLC1222
A	OLC1223
A	HOH1391

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGE A 1214

Chain	Residue
A	OLA1209

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLA A 1215

Chain	Residue
A	VAL272
A	OLA1205

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 1216

Chain	Residue
A	ARG261
A	VAL316
A	PHE320

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 1217

Chain	Residue
A	PRO115
A	PHE116
A	OLA1201

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TLA A 1218

Chain	Residue
A	THR82
A	ALA83
A	THR84
A	ARG146
A	ARG160
A	ILE259
A	HOH1328
A	HOH1340

site_id	BC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE EJ4 A 1219

Chain	Residue
A	ASP128
A	TYR129
A	MET132
A	LYS214
A	VAL217
A	TRP274
A	VAL281
A	TRP284
A	ILE304
A	GLY307
A	TYR308
A	HOH1312
A	HOH1316
A	HOH1324
A	HOH1336

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1220

Chain	Residue
A	ASP95
A	ASN131
A	SER135
A	HOH1307
A	HOH1308

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE OLC A 1222

Chain	Residue
A	LYS81
A	ILE86
A	PHE89
A	LYS166
A	ASN169
A	TRP173
A	SER177
A	MET184
A	OLC1212

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE OLC A 1223

Chain	Residue
A	LYS122
A	TYR130
A	LEU167
A	ILE170
A	MET184
A	VAL185
A	OLC1212
A	HOH1366

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMSVDRYIaV

Chain	Residue	Details
A	THR134-VAL150

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	49
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	44
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	31
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)