4N4I

Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.3K36me3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003714	molecular_function	transcription corepressor activity
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS258
A	CYS261
A	CYS277
A	HIS281

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 402

Chain	Residue
A	LYS345
A	HOH550
A	HOH571
A	ARG268
A	HIS313
A	HIS313
A	HIS314
A	HIS315

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 403

Chain	Residue
A	ALA220
A	ALA241
A	TYR245
A	THR248

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	51
Details	Domain: {"description":"PWWP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00162","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	19
Details	Region: {"description":"Aromatic cage required for H3.3K36me3-specific binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24590075","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N4I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Interaction with ZMYND11","evidences":[{"source":"PubMed","id":"24590075","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15851689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7309716","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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