4N3S

Crystal structure of eukaryotic translation initiation factor eIF5B (399-852) from Saccharomyces cerevisiae, apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 901

Chain	Residue
A	ARG661
A	VAL724
A	GLU730
A	HOH1156
A	HOH1224

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 902

Chain	Residue
B	PHE643
B	GLY644
B	HOH1048
A	LYS690
A	HOH1004
A	HOH1193
A	HOH1284

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 903

Chain	Residue
A	LEU635
A	GLU636
A	VAL637
A	SER717

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 904

Chain	Residue
A	LEU517
A	ALA767
A	HOH1207

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 901

Chain	Residue
B	LEU403
B	ASP468
B	VAL469
B	PRO470
B	HOH1338
B	HOH1344

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"G0S8G9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24686316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---