4N09
Structure of Trypanosoma brucei brucei adenosine kinase in complex with adenosine and AMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0044209 | biological_process | AMP salvage |
| A | 0097014 | cellular_component | ciliary plasm |
| B | 0004001 | molecular_function | adenosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0020015 | cellular_component | glycosome |
| B | 0044209 | biological_process | AMP salvage |
| B | 0097014 | cellular_component | ciliary plasm |
| C | 0004001 | molecular_function | adenosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006144 | biological_process | purine nucleobase metabolic process |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0020015 | cellular_component | glycosome |
| C | 0044209 | biological_process | AMP salvage |
| C | 0097014 | cellular_component | ciliary plasm |
| D | 0004001 | molecular_function | adenosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006144 | biological_process | purine nucleobase metabolic process |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0020015 | cellular_component | glycosome |
| D | 0044209 | biological_process | AMP salvage |
| D | 0097014 | cellular_component | ciliary plasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADN A 401 |
| Chain | Residue |
| A | ASN13 |
| A | ASP299 |
| A | LEU15 |
| A | ASP17 |
| A | LEU39 |
| A | GLY63 |
| A | SER64 |
| A | ASN67 |
| A | ALA136 |
| A | PHE169 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 402 |
| Chain | Residue |
| A | ASN222 |
| A | THR264 |
| A | ARG265 |
| A | ASP266 |
| A | THR270 |
| A | GLN288 |
| A | MET294 |
| A | ALA297 |
| A | GLY298 |
| A | HIS323 |
| A | ALA326 |
| A | GLN327 |
| A | ILE330 |
| A | EDO403 |
| A | HOH510 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | ASN195 |
| A | ALA221 |
| A | ASN222 |
| A | GLU225 |
| A | THR264 |
| A | GLY298 |
| A | ADP402 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADN B 401 |
| Chain | Residue |
| B | ASN13 |
| B | LEU15 |
| B | ASP17 |
| B | LEU39 |
| B | GLY63 |
| B | SER64 |
| B | ASN67 |
| B | ALA136 |
| B | PHE169 |
| B | ASP299 |
| B | HOH511 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP B 402 |
| Chain | Residue |
| B | ASN222 |
| B | THR264 |
| B | ARG265 |
| B | ASP266 |
| B | THR270 |
| B | VAL283 |
| B | GLN288 |
| B | MET294 |
| B | ALA297 |
| B | GLY298 |
| B | HIS323 |
| B | ALA326 |
| B | GLN327 |
| B | ILE330 |
| B | EDO403 |
| B | HOH504 |
| B | HOH512 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | ASN195 |
| B | GLU225 |
| B | THR264 |
| B | GLY298 |
| B | ADP402 |
| B | HOH535 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADN C 401 |
| Chain | Residue |
| C | ASN13 |
| C | LEU15 |
| C | ASP17 |
| C | LEU39 |
| C | GLY63 |
| C | SER64 |
| C | ASN67 |
| C | ALA136 |
| C | PHE169 |
| C | GLY296 |
| C | ASP299 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP C 402 |
| Chain | Residue |
| C | ASN222 |
| C | THR264 |
| C | ARG265 |
| C | ASP266 |
| C | ILE267 |
| C | THR270 |
| C | VAL283 |
| C | GLN288 |
| C | MET294 |
| C | GLY298 |
| C | HIS323 |
| C | ALA326 |
| C | GLN327 |
| C | ILE330 |
| C | HOH512 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADN D 401 |
| Chain | Residue |
| D | LEU134 |
| D | ALA136 |
| D | PHE169 |
| D | ASN295 |
| D | GLY296 |
| D | ASP299 |
| D | ASN13 |
| D | LEU15 |
| D | ASP17 |
| D | LEU39 |
| D | GLY63 |
| D | SER64 |
| D | ASN67 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP D 402 |
| Chain | Residue |
| D | ASN222 |
| D | THR264 |
| D | ARG265 |
| D | ASP266 |
| D | THR270 |
| D | VAL283 |
| D | GLN288 |
| D | MET294 |
| D | ALA297 |
| D | GLY298 |
| D | HIS323 |
| D | ALA326 |
| D | GLN327 |
| D | ILE330 |
| D | HOH514 |
