Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4MX3

Crystal Structure of PKA RIalpha Homodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001707biological_processmesoderm formation
A0001772cellular_componentimmunological synapse
A0001932biological_processregulation of protein phosphorylation
A0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005771cellular_componentmultivesicular body
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007507biological_processheart development
A0008603molecular_functioncAMP-dependent protein kinase regulator activity
A0010629biological_processnegative regulation of gene expression
A0016020cellular_componentmembrane
A0019904molecular_functionprotein domain specific binding
A0030552molecular_functioncAMP binding
A0031588cellular_componentnucleotide-activated protein kinase complex
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032024biological_processpositive regulation of insulin secretion
A0032991cellular_componentprotein-containing complex
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0042802molecular_functionidentical protein binding
A0044853cellular_componentplasma membrane raft
A0045202cellular_componentsynapse
A0045214biological_processsarcomere organization
A0046007biological_processnegative regulation of activated T cell proliferation
A0060038biological_processcardiac muscle cell proliferation
A0071377biological_processcellular response to glucagon stimulus
A0098978cellular_componentglutamatergic synapse
A0120212cellular_componentsperm head-tail coupling apparatus
A0141162biological_processnegative regulation of cAMP/PKA signal transduction
B0000166molecular_functionnucleotide binding
B0001707biological_processmesoderm formation
B0001772cellular_componentimmunological synapse
B0001932biological_processregulation of protein phosphorylation
B0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005771cellular_componentmultivesicular body
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0005952cellular_componentcAMP-dependent protein kinase complex
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007507biological_processheart development
B0008603molecular_functioncAMP-dependent protein kinase regulator activity
B0010629biological_processnegative regulation of gene expression
B0016020cellular_componentmembrane
B0019904molecular_functionprotein domain specific binding
B0030552molecular_functioncAMP binding
B0031588cellular_componentnucleotide-activated protein kinase complex
B0031594cellular_componentneuromuscular junction
B0031625molecular_functionubiquitin protein ligase binding
B0032024biological_processpositive regulation of insulin secretion
B0032991cellular_componentprotein-containing complex
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0042802molecular_functionidentical protein binding
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045214biological_processsarcomere organization
B0046007biological_processnegative regulation of activated T cell proliferation
B0060038biological_processcardiac muscle cell proliferation
B0071377biological_processcellular response to glucagon stimulus
B0098978cellular_componentglutamatergic synapse
B0120212cellular_componentsperm head-tail coupling apparatus
B0141162biological_processnegative regulation of cAMP/PKA signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE CMP A 401
ChainResidue
APHE198
BASN218
AGLY199
AGLU200
ALEU201
AALA202
AARG209
AALA210
AASP258
ATRP260

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CMP A 402
ChainResidue
AVAL300
AVAL313
APHE322
AGLY323
AGLU324
AILE325
AALA326
AARG333
AALA334
AASN372
ASER373

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CMP B 401
ChainResidue
BILE163
BVAL182
BALA189
BGLY199
BGLU200
BLEU201
BALA202
BARG209
BALA210
BALA211
BVAL213
BASP258
BTRP260

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE CMP B 402
ChainResidue
BVAL300
BVAL313
BPHE322
BGLY323
BGLU324
BILE325
BALA326
BARG333
BALA334
BVAL337
BASN372
BSER373

Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIqQGDeGDnFYVIdqG
ChainResidueDetails
AVAL162-GLY178
AILE280-GLY296

site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALiygtp......RAAtVkA
ChainResidueDetails
APHE198-ALA215
APHE322-ALA339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING:
ChainResidueDetails
ALEU135
BILE253
BGLU324
BARG333
AGLU200
AARG209
AILE253
AGLU324
AARG333
BLEU135
BGLU200
BARG209

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylalanine; in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed => ECO:0000269|PubMed:6487597
ChainResidueDetails
AALA1
BALA1

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09456
ChainResidueDetails
ASER2
ASER256
BSER2
BSER256

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10644
ChainResidueDetails
ASER75
ASER81
BSER75
BSER81

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9DBC7
ChainResidueDetails
ASER99
BSER99

237992

PDB entries from 2025-06-25

PDB statisticsPDBj update infoContact PDBjnumon