Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4MX2

Crystal Structure of adenylosuccinate lyase from Leishmania donovani

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006188	biological_process	IMP biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009152	biological_process	purine ribonucleotide biosynthetic process
A	0016829	molecular_function	lyase activity
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006188	biological_process	IMP biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009152	biological_process	purine ribonucleotide biosynthetic process
B	0016829	molecular_function	lyase activity
B	0044208	biological_process	'de novo' AMP biosynthetic process
B	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006188	biological_process	IMP biosynthetic process
C	0006189	biological_process	'de novo' IMP biosynthetic process
C	0009152	biological_process	purine ribonucleotide biosynthetic process
C	0016829	molecular_function	lyase activity
C	0044208	biological_process	'de novo' AMP biosynthetic process
C	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006188	biological_process	IMP biosynthetic process
D	0006189	biological_process	'de novo' IMP biosynthetic process
D	0009152	biological_process	purine ribonucleotide biosynthetic process
D	0016829	molecular_function	lyase activity
D	0044208	biological_process	'de novo' AMP biosynthetic process
D	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006188	biological_process	IMP biosynthetic process
E	0006189	biological_process	'de novo' IMP biosynthetic process
E	0009152	biological_process	purine ribonucleotide biosynthetic process
E	0016829	molecular_function	lyase activity
E	0044208	biological_process	'de novo' AMP biosynthetic process
E	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006188	biological_process	IMP biosynthetic process
F	0006189	biological_process	'de novo' IMP biosynthetic process
F	0009152	biological_process	purine ribonucleotide biosynthetic process
F	0016829	molecular_function	lyase activity
F	0044208	biological_process	'de novo' AMP biosynthetic process
F	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006188	biological_process	IMP biosynthetic process
G	0006189	biological_process	'de novo' IMP biosynthetic process
G	0009152	biological_process	purine ribonucleotide biosynthetic process
G	0016829	molecular_function	lyase activity
G	0044208	biological_process	'de novo' AMP biosynthetic process
G	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006188	biological_process	IMP biosynthetic process
H	0006189	biological_process	'de novo' IMP biosynthetic process
H	0009152	biological_process	purine ribonucleotide biosynthetic process
H	0016829	molecular_function	lyase activity
H	0044208	biological_process	'de novo' AMP biosynthetic process
H	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE AMP A 501

Chain	Residue
A	ASN117
A	SER366
A	THR367
A	ARG370
A	HOH640
A	HOH656
A	HOH660
A	HOH718
B	ARG40
B	TYR41
B	ILE331
A	HIS118
B	ASN335
B	HOH702
E	HIS196
A	ASP119
A	SER149
A	GLN150
A	ASN153
A	GLN273
A	ARG361
A	LEU363

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE AMP B 501

Chain	Residue
A	ARG40
A	TYR41
A	ILE331
A	ASN335
A	HOH713
B	ASN117
B	HIS118
B	ASP119
B	SER149
B	GLN150
B	GLN273
B	ARG361
B	LEU363
B	SER366
B	THR367
B	ARG370
B	HOH614
B	HOH722
B	HOH758
B	HOH812
B	HOH820
F	HIS196

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE AMP C 501

Chain	Residue
C	ASN117
C	HIS118
C	ASP119
C	SER149
C	GLN150
C	GLN273
C	ARG361
C	LEU363
C	SER366
C	THR367
C	ARG370
C	HOH617
C	HOH627
C	HOH648
C	HOH767
C	HOH779
D	ARG40
D	TYR41
D	ILE331
D	ASN335
D	HOH717
G	HIS196

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
C	LYS121
C	HIS144
C	LEU147
C	THR148
C	SER149
C	HOH647
C	HOH663
G	HOH795

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE AMP D 501

Chain	Residue
C	ARG40
C	TYR41
C	ASN335
C	HOH692
D	ASN117
D	HIS118
D	ASP119
D	SER149
D	GLN150
D	ASN153
D	GLN273
D	ARG361
D	SER366
D	THR367
D	ARG370
D	HOH626
D	HOH627
D	HOH687
D	HOH692
D	HOH788
H	HIS196

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 501

Chain	Residue
E	ASP365
E	SER366
E	LEU369
E	GLN150
E	ASN153
E	ILE157
E	ARG361

site_id	AC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE AMP E 502

Chain	Residue
A	HIS196
E	ASN117
E	HIS118
E	ASP119
E	SER149
E	GLN150
E	GLN273
E	ARG361
E	SER366
E	THR367
E	ARG370
E	HOH628
E	HOH630
E	HOH648
E	HOH691
E	HOH705
F	ARG40
F	TYR41
F	ILE331
F	ASN335
F	HOH753

site_id	AC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE AMP F 501

Chain	Residue
B	HIS196
E	ARG40
E	TYR41
E	ILE331
E	ASN335
E	HOH735
F	ASN117
F	HIS118
F	ASP119
F	SER149
F	GLN150
F	ASN153
F	GLN273
F	ARG361
F	LEU363
F	SER366
F	THR367
F	ARG370
F	HOH618
F	HOH699
F	HOH770
F	HOH799

site_id	AC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE AMP G 501

Chain	Residue
C	HIS196
C	HOH750
G	ASN117
G	HIS118
G	ASP119
G	SER149
G	GLN150
G	GLN273
G	ARG361
G	LEU363
G	SER366
G	THR367
G	ARG370
G	HOH615
G	HOH646
G	HOH663
H	ARG40
H	TYR41
H	ILE331
H	ASN335
H	HOH628
H	HOH718

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 502

Chain	Residue
G	LYS121
G	HIS144
G	LEU147
G	THR148
G	SER149
G	HOH813

site_id	BC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE AMP H 501

Chain	Residue
D	HIS196
G	ARG40
G	TYR41
G	ILE331
G	ASN335
G	HOH728
H	ASN117
H	HIS118
H	ASP119
H	SER149
H	GLN150
H	GLN273
H	ARG361
H	LEU363
H	SER366
H	THR367
H	ARG370
H	HOH623
H	HOH624
H	HOH651
H	HOH735
H	HOH745
H	HOH755

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 502

Chain	Residue
H	LYS121
H	HIS144
H	THR148
H	SER149
H	HOH711
H	HOH853

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSsaMpHKvN

Chain	Residue	Details
A	GLY320-ASN329

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)