4MVT

Crystal structure of SUMO E3 Ligase PIAS3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
B	0008270	molecular_function	zinc ion binding
C	0008270	molecular_function	zinc ion binding
D	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS343
A	HIS345
A	CYS366
A	CYS369

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 502

Chain	Residue
A	ASN296
A	HIS299
B	ASN296
B	HIS299

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	HIS345
B	CYS366
B	CYS369
B	CYS343

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	CYS343
C	HIS345
C	CYS366
C	CYS369

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 502

Chain	Residue
C	ASN296
C	HIS299
D	ASN296
D	HIS299

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 501

Chain	Residue
D	CYS343
D	HIS345
D	CYS366
D	CYS369

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	324
Details	ZN_FING: SP-RING-type => ECO:0000255|PROSITE-ProRule:PRU00452

Chain	Residue	Details
A	PRO312-ASP393
B	PRO312-ASP393
C	PRO312-ASP393
D	PRO312-ASP393

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00452

Chain	Residue	Details
A	CYS343
C	HIS345
C	CYS366
C	CYS369
D	CYS343
D	HIS345
D	CYS366
D	CYS369
A	HIS345
A	CYS366
A	CYS369
B	CYS343
B	HIS345
B	CYS366
B	CYS369
C	CYS343

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS230
B	LYS230
C	LYS230
D	LYS230

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS466
B	LYS466
C	LYS466
D	LYS466

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS307
B	LYS307
C	LYS307
D	LYS307

---