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4MUV

M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP bound

Functional Information from GO Data
ChainGOidnamespacecontents
A0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
B0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE PCG A 401
ChainResidue
ASER284
AVAL311
AARG348
AASP352
AHOH501
AHOH506
AHOH508
AHOH519
AHOH531
APHE296
AGLY297
AGLU298
AMET299
AALA300
AARG307
ASER308
AALA309

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 402
ChainResidue
AVAL218
AASP222
AARG252
AARG254
AHOH573
BHOH529

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE PCG B 401
ChainResidue
BPHE296
BGLY297
BGLU298
BMET299
BALA300
BARG307
BSER308
BALA309
BVAL311
BARG348
BASP352
BHOH501
BHOH506
BHOH507
BHOH509
BHOH512

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA B 402
ChainResidue
BPHE236
BGLN237
BLEU239
BLEU244
BTHR310

Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrIGEpGDrMFFVveG
ChainResidueDetails
AILE262-GLY278

site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALisgep......RSAtVsA
ChainResidueDetails
APHE296-ALA313

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0007744|PDB:1VP6
ChainResidueDetails
AGLY297
AARG307
AARG348
BGLY297
BARG307
BARG348

226707

PDB entries from 2024-10-30

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