4MUM

Crystal structure of mitochondrial 5'(3')-deoxy ribonucleotidase alternative spliced variant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008253	molecular_function	5'-nucleotidase activity
A	0009264	biological_process	deoxyribonucleotide catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 301

Chain	Residue
A	ASP41
A	ASP43
A	ASP176
A	PO4302
A	HOH401
A	HOH402

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 A 302

Chain	Residue
A	THR130
A	SER131
A	LYS143
A	LYS165
A	MG301
A	GOL303
A	TRS314
A	HOH401
A	HOH402
A	HOH408
A	ASP41
A	MET42
A	ASP43

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	PHE49
A	GLU50
A	PHE75
A	HIS204
A	PO4302
A	GOL305
A	TRS314
A	HOH401
A	HOH457
A	HOH645

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 304

Chain	Residue
A	ASN100
A	PHE103
A	LYS137
A	TYR141
A	PEG311
A	HOH431
A	HOH504
A	HOH580
A	HOH583
A	HOH610

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 305

Chain	Residue
A	PHE49
A	PHE75
A	TRP76
A	VAL77
A	TRP96
A	ILE133
A	GOL303
A	GOL306
A	TRS314
A	HOH449
A	HOH548
A	HOH645

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 306

Chain	Residue
A	TRP96
A	GLU97
A	ILE133
A	LYS134
A	MET135
A	GOL305
A	HOH548
A	HOH614

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 307

Chain	Residue
A	SER27
A	ASN28
A	ALA119
A	THR124
A	ASP125
A	VAL126
A	GLN158
A	HOH508

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 308

Chain	Residue
A	ASP48
A	GLY51
A	GLY52
A	ARG55
A	GLU106
A	PG4313
A	CL315
A	HOH629

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 309

Chain	Residue
A	GLY110
A	GLU113
A	ALA114
A	TRP220
A	ALA221
A	ASP222
A	TRP224
A	HOH485
A	HOH575

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GOL A 310

Chain	Residue
A	ASP48
A	LEU69
A	GLU90
A	ALA202
A	CYS203
A	HOH418
A	HOH419
A	HOH457
A	HOH474
A	HOH536
A	HOH582
A	HOH687
A	HOH688

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG A 311

Chain	Residue
A	PRO213
A	ARG214
A	ARG215
A	GOL304
A	HOH463
A	HOH593
A	HOH610
A	PHE103
A	LYS149

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 312

Chain	Residue
A	PRO132
A	ILE133
A	LYS134
A	LEU156
A	ARG163
A	HOH550

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 A 313

Chain	Residue
A	ASP48
A	LYS91
A	GLU106
A	PRO107
A	LEU108
A	PRO109
A	GOL308
A	HOH475

---

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TRS A 314

Chain	Residue
A	ASP43
A	PHE49
A	PHE75
A	SER131
A	PRO132
A	ILE133
A	ARG163
A	PO4302
A	GOL303
A	GOL305
A	HOH408
A	HOH585
A	HOH644
A	HOH645
A	HOH647

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 315

Chain	Residue
A	ASP48
A	GLY52
A	LEU105
A	GLU106
A	GOL308
A	HOH432

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12352955","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 812

Chain	Residue	Details
A	ASP41	covalently attached, metal ligand, nucleofuge, nucleophile
A	ASP43	metal ligand
A	ASP176	metal ligand

---