4MTH

Crystal structure of mature human RegIIIalpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0007157	biological_process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009609	biological_process	response to symbiotic bacterium
A	0009611	biological_process	response to wounding
A	0010838	biological_process	positive regulation of keratinocyte proliferation
A	0030246	molecular_function	carbohydrate binding
A	0038023	molecular_function	signaling receptor activity
A	0042802	molecular_function	identical protein binding
A	0042834	molecular_function	peptidoglycan binding
A	0043434	biological_process	response to peptide hormone
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0045617	biological_process	negative regulation of keratinocyte differentiation
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070492	molecular_function	oligosaccharide binding
A	0090303	biological_process	positive regulation of wound healing
A	0090594	biological_process	inflammatory response to wounding
A	0106015	biological_process	negative regulation of inflammatory response to wounding
A	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
A	2000972	biological_process	positive regulation of detection of glucose

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	HIS107
A	GLU121
A	ASP175
A	HOH335

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 202

Chain	Residue
A	HOH447
A	HOH473
A	HIS50
A	HOH318
A	HOH354
A	HOH413
A	HOH444

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 203

Chain	Residue
A	HIS145
A	HOH465
A	HOH469

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Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	26
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CAslsrstaflr..WKDYNCnvrlp.YVC

Chain	Residue	Details
A	CYS146-CYS171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24256734, ECO:0007744|PDB:4MTH

Chain	Residue	Details
A	HIS50
A	HIS107
A	GLU121
A	HIS145

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