4MTH
Crystal structure of mature human RegIIIalpha
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006953 | biological_process | acute-phase response |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007157 | biological_process | heterophilic cell-cell adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009609 | biological_process | response to symbiotic bacterium |
| A | 0009611 | biological_process | response to wounding |
| A | 0010838 | biological_process | positive regulation of keratinocyte proliferation |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042834 | molecular_function | peptidoglycan binding |
| A | 0043434 | biological_process | response to peptide hormone |
| A | 0045617 | biological_process | negative regulation of keratinocyte differentiation |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| A | 0070492 | molecular_function | oligosaccharide binding |
| A | 0090303 | biological_process | positive regulation of wound healing |
| A | 0106015 | biological_process | negative regulation of inflammatory response to wounding |
| A | 2000972 | biological_process | positive regulation of detection of glucose |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 201 |
| Chain | Residue |
| A | HIS107 |
| A | GLU121 |
| A | ASP175 |
| A | HOH335 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 202 |
| Chain | Residue |
| A | HOH447 |
| A | HOH473 |
| A | HIS50 |
| A | HOH318 |
| A | HOH354 |
| A | HOH413 |
| A | HOH444 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 203 |
| Chain | Residue |
| A | HIS145 |
| A | HOH465 |
| A | HOH469 |
Functional Information from PROSITE/UniProt
| site_id | PS00615 |
| Number of Residues | 26 |
| Details | C_TYPE_LECTIN_1 C-type lectin domain signature. CAslsrstaflr..WKDYNCnvrlp.YVC |
| Chain | Residue | Details |
| A | CYS146-CYS171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Region: {"description":"Sufficient to activate EXTL3","evidences":[{"source":"PubMed","id":"19158046","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"EPN","evidences":[{"source":"PubMed","id":"20382864","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GO0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24256734","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MTH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
