4MSD

Crystal structure of Schizosaccharomyces pombe AMSH-like protein SST2 T319I mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016579	biological_process	protein deubiquitination
A	0061578	molecular_function	K63-linked deubiquitinase activity
A	0070536	biological_process	protein K63-linked deubiquitination
A	0140492	molecular_function	metal-dependent deubiquitinase activity
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0016579	biological_process	protein deubiquitination
B	0061578	molecular_function	K63-linked deubiquitinase activity
B	0070536	biological_process	protein K63-linked deubiquitination
B	0140492	molecular_function	metal-dependent deubiquitinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS341
A	HIS343
A	ASP354
A	HOH621

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	HIS356
A	CYS397
A	HIS404
A	HIS406

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 503

Chain	Residue
A	GLY318
A	ILE319
A	THR357
A	TYR361
A	EDO509
A	CYS317

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 504

Chain	Residue
A	LYS409
A	TYR411
A	MET413
A	EDO508

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 505

Chain	Residue
A	GLN346
A	EDO507
A	HOH603
A	HOH635

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 506

Chain	Residue
A	SER360
A	HOH647

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 507

Chain	Residue
A	PHE349
A	SER351
A	SER352
A	PHE403
A	EDO505

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 508

Chain	Residue
A	LYS409
A	THR412
A	MET413
A	EDO504

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 509

Chain	Residue
A	THR316
A	CYS317
A	VAL353
A	THR357
A	EDO503
A	HOH637

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DTT A 510

Chain	Residue
A	ARG296
A	HOH632

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	HIS341
B	HIS343
B	ASP354
B	HOH624

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	HIS356
B	CYS397
B	HIS404
B	HIS406

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 503

Chain	Residue
B	LYS409
B	TYR411

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 504

Chain	Residue
B	ASP315
B	HIS343
B	GLN346
B	PHE349
B	SER351
B	HOH603
B	HOH604
B	HOH642

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 505

Chain	Residue
B	CYS288
B	CYS317
B	GLY318
B	THR357
B	TYR361

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 506

Chain	Residue
B	PHE349

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 508

Chain	Residue
B	MET364
B	HOH611

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 509

Chain	Residue
B	ASP315

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	260
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Indirect zinc-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---