4MQK

Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005833	cellular_component	hemoglobin complex
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005829	cellular_component	cytosol
E	0005833	cellular_component	hemoglobin complex
E	0015670	biological_process	carbon dioxide transport
E	0015671	biological_process	oxygen transport
E	0016020	cellular_component	membrane
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0030185	biological_process	nitric oxide transport
E	0031720	molecular_function	haptoglobin binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042542	biological_process	response to hydrogen peroxide
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0043177	molecular_function	organic acid binding
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	0071682	cellular_component	endocytic vesicle lumen
E	0072562	cellular_component	blood microparticle
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005833	cellular_component	hemoglobin complex
F	0015670	biological_process	carbon dioxide transport
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0031720	molecular_function	haptoglobin binding
F	0031721	molecular_function	hemoglobin alpha binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0043177	molecular_function	organic acid binding
F	0046872	molecular_function	metal ion binding
F	0072562	cellular_component	blood microparticle
F	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005829	cellular_component	cytosol
G	0005833	cellular_component	hemoglobin complex
G	0015670	biological_process	carbon dioxide transport
G	0015671	biological_process	oxygen transport
G	0016020	cellular_component	membrane
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0030185	biological_process	nitric oxide transport
G	0031720	molecular_function	haptoglobin binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042542	biological_process	response to hydrogen peroxide
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0071682	cellular_component	endocytic vesicle lumen
G	0072562	cellular_component	blood microparticle
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005833	cellular_component	hemoglobin complex
H	0015670	biological_process	carbon dioxide transport
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0031720	molecular_function	haptoglobin binding
H	0031721	molecular_function	hemoglobin alpha binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0043177	molecular_function	organic acid binding
H	0046872	molecular_function	metal ion binding
H	0072562	cellular_component	blood microparticle
H	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM A 201

Chain	Residue
A	TYR42
A	PHE98
A	LEU101
A	LEU136
A	CMO202
A	HOH310
A	HOH312
A	HOH318
G	SER3
G	ALA5
H	SER50
A	PHE43
H	SER52
A	HIS58
A	LYS61
A	LEU86
A	HIS87
A	LEU91
A	VAL93
A	ASN97

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO A 202

Chain	Residue
A	HIS58
A	VAL62
A	HEM201

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM B 201

Chain	Residue
B	PHE41
B	PHE42
B	HIS63
B	LYS66
B	MET67
B	SER70
B	LEU91
B	HIS92
B	LEU96
B	ASN102
B	LEU106
B	VAL137
B	LEU141
B	CMO202
D	LYS65

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO B 202

Chain	Residue
B	HIS63
B	MET67
B	HEM201

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM C 201

Chain	Residue
C	TYR42
C	PHE43
C	PHE46
C	HIS58
C	LYS61
C	LEU83
C	LEU86
C	HIS87
C	LEU91
C	ASN97
C	PHE98
C	LEU101
C	LEU136
C	CMO202
C	HOH315
C	HOH329
C	HOH343
E	SER3
E	ALA5
F	SER50
F	SER52
F	HOH306

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CMO C 202

Chain	Residue
C	LEU29
C	HIS58
C	VAL62
C	HEM201

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM D 201

Chain	Residue
D	PHE41
D	PHE42
D	HIS63
D	LYS66
D	MET67
D	LEU91
D	HIS92
D	LEU96
D	ASN102
D	PHE103
D	LEU106
D	VAL137
D	LEU141
D	CMO202

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO D 202

Chain	Residue
D	HIS63
D	MET67
D	HEM201

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM E 201

Chain	Residue
E	TYR42
E	PHE43
E	PHE46
E	HIS58
E	LYS61
E	HIS87
E	LEU91
E	ASN97
E	PHE98
E	LEU101
E	VAL132
E	HOH325
F	LYS76

---

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM F 201

Chain	Residue
F	HIS63
F	LYS66
F	SER70
F	LEU88
F	LEU91
F	HIS92
F	LEU96
F	ASN102
F	PHE103
F	LEU106
F	VAL137
F	LEU141
F	CMO202
F	PHE41
F	PHE42

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO F 202

Chain	Residue
F	HIS63
F	MET67
F	HEM201

---

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM G 201

Chain	Residue
G	TYR42
G	PHE43
G	PHE46
G	HIS58
G	LYS61
G	LEU83
G	LEU86
G	HIS87
G	ASN97
G	PHE98
G	LEU101
G	LEU136
G	HOH329
G	HOH330
H	HIS77

---

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM H 201

Chain	Residue
G	ASN78
H	PHE41
H	PHE42
H	HIS63
H	LYS66
H	MET67
H	SER70
H	LEU88
H	LEU91
H	HIS92
H	LYS95
H	LEU96
H	ASN102
H	LEU106
H	LEU141
H	CMO202

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO H 202

Chain	Residue
H	HIS63
H	MET67
H	HEM201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: distal binding residue => ECO:0000250|UniProtKB:P80044

Chain	Residue	Details
B	HIS63
D	HIS63
F	HIS63
H	HIS63

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: proximal binding residue => ECO:0000269|PubMed:881729, ECO:0007744|PDB:1FDH, ECO:0007744|PDB:4MQJ, ECO:0007744|PDB:4MQK

Chain	Residue	Details
B	HIS92
D	HIS92
F	HIS92
H	HIS92

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylglycine; in form Hb F1 => ECO:0000269|PubMed:5554303

Chain	Residue	Details
B	GLY1
A	LEU91
A	LEU106
A	THR108
A	VAL121
A	SER133
C	THR8
C	ALA13
C	TYR24
C	LEU29
C	HIS45
D	GLY1
C	ASP47
C	SER52
C	VAL55
C	GLY59
C	LEU91
C	LEU106
C	THR108
C	VAL121
C	SER133
E	THR8
F	GLY1
E	ALA13
E	TYR24
E	LEU29
E	HIS45
E	ASP47
E	SER52
E	VAL55
E	GLY59
E	LEU91
E	LEU106
H	GLY1
E	THR108
E	VAL121
E	SER133
G	THR8
G	ALA13
G	TYR24
G	LEU29
G	HIS45
G	ASP47
G	SER52
A	HIS45
G	VAL55
G	GLY59
G	LEU91
G	LEU106
G	THR108
G	VAL121
G	SER133
A	ASP47
A	SER52
A	VAL55
A	GLY59

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	THR12
C	LYS99
E	LYS11
E	LYS56
E	LYS60
E	LYS90
E	LYS99
G	LYS11
G	LYS56
G	LYS60
G	LYS90
D	THR12
G	LYS99
F	THR12
H	THR12
A	LYS99
C	LYS11
C	LYS56
C	LYS60
C	LYS90

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER44
D	SER139
D	SER142
D	SER143
F	SER44
F	SER50
F	SER52
F	SER139
F	SER142
F	SER143
H	SER44
B	SER50
H	SER50
H	SER52
H	SER139
H	SER142
H	SER143
B	SER52
B	SER139
B	SER142
B	SER143
D	SER44
D	SER50
D	SER52

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	LYS59
G	LYS7
G	LYS16
G	LYS40
B	LYS82
D	LYS59
D	LYS82
F	LYS59
F	LYS82
H	LYS59
H	LYS82
E	LYS40

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	CYS93
D	CYS93
F	CYS93
H	CYS93

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	LYS11
C	LYS11
E	LYS11
G	LYS11

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR24
C	TYR24
E	TYR24
G	TYR24

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	SER102
E	SER124
E	SER131
E	SER138
G	SER102
G	SER124
G	SER131
G	SER138
A	SER124
A	SER131
A	SER138
C	SER102
C	SER124
C	SER131
C	SER138
E	SER102

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	THR108
G	THR108
G	THR134
G	THR137
A	THR134
A	THR137
C	THR108
C	THR134
C	THR137
E	THR108
E	THR134
E	THR137

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

Chain	Residue	Details
A	LYS7
G	LYS7
G	LYS16
G	LYS40
A	LYS16
A	LYS40
C	LYS7
C	LYS16
C	LYS40
E	LYS7
E	LYS16
E	LYS40

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
A	LYS61
C	LYS61
E	LYS61
G	LYS61

---