4MP0

Structure of a second nuclear PP1 Holoenzyme, crystal form 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
C	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 401

Chain	Residue
A	ASP64
A	HIS66
A	ASP92
A	MN402
A	PO4405
A	HOH538
A	HOH642

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 402

Chain	Residue
A	HIS173
A	HIS248
A	MN401
A	PO4405
A	HOH642
A	ASP92
A	ASN124

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	PRO50
A	LEU53
A	GLU54
A	GLU116
A	PHE119

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	CYS127
A	SER129
A	VAL195
A	PRO196
A	ASP197
A	TRP206
C	HOH510

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 A 405

Chain	Residue
A	HIS66
A	ASP92
A	ARG96
A	ASN124
A	HIS125
A	ARG221
A	HIS248
A	MN401
A	MN402
A	HOH520
A	HOH538
A	HOH576
A	HOH594
A	HOH642

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN C 401

Chain	Residue
C	ASP64
C	HIS66
C	ASP92
C	MN402
C	PO4403
C	HOH566
C	HOH567

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN C 402

Chain	Residue
C	ASP92
C	ASN124
C	HIS173
C	HIS248
C	MN401
C	PO4403
C	HOH566

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 C 403

Chain	Residue
C	HIS66
C	ASP92
C	ARG96
C	ASN124
C	HIS125
C	ARG221
C	HIS248
C	MN401
C	MN402
C	HOH557
C	HOH566
C	HOH567

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"PubMed","id":"12574161","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---