4MJR
E. coli sliding clamp in complex with (S)-Carprofen
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044787 | biological_process | bacterial-type DNA replication |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006261 | biological_process | DNA-templated DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| B | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| B | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044787 | biological_process | bacterial-type DNA replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PGE A 401 |
| Chain | Residue |
| A | PRO83 |
| A | GLU84 |
| A | GLY85 |
| A | ALA86 |
| A | GLU87 |
| A | ARG100 |
| A | SER101 |
| A | GLY102 |
| A | HOH541 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 402 |
| Chain | Residue |
| A | LYS277 |
| B | HIS9 |
| B | THR41 |
| B | ARG56 |
| B | VAL57 |
| B | ALA58 |
| B | ASP229 |
| B | HOH745 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 403 |
| Chain | Residue |
| A | GLU6 |
| A | HIS9 |
| A | GLN61 |
| A | HOH504 |
| B | HOH527 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0LA A 404 |
| Chain | Residue |
| A | ARG152 |
| A | TYR154 |
| A | THR172 |
| A | GLY174 |
| A | ARG176 |
| A | LEU177 |
| A | VAL247 |
| A | VAL360 |
| A | MET362 |
| B | HOH637 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 401 |
| Chain | Residue |
| A | SER181 |
| A | SER356 |
| B | ARG365 |
| B | HOH636 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG B 402 |
| Chain | Residue |
| A | GLU6 |
| A | GLU8 |
| A | GLY85 |
| A | GLU87 |
| A | HOH756 |
| A | HOH776 |
| B | ASP120 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 403 |
| Chain | Residue |
| B | SER18 |
| B | ARG73 |
| B | PHE76 |
| B | ARG80 |
| B | HOH755 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 404 |
| Chain | Residue |
| A | TRP122 |
| A | GLN217 |
| A | ARG224 |
| A | HOH680 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 405 |
| Chain | Residue |
| B | GLU334 |
| B | ASN335 |
| B | ASP351 |
| B | ALA353 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 406 |
| Chain | Residue |
| B | ALA89 |
| B | LEU98 |
| B | ARG100 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 407 |
| Chain | Residue |
| A | PHE278 |
| B | GLU6 |
| B | GLN61 |
| B | HOH608 |
| B | HOH623 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Region: {"description":"2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | Region: {"description":"3","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
