4MHZ
Crystal structure of apo-form glutaminyl cyclase from Ixodes scapularis in complex with PBD150
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016603 | molecular_function | glutaminyl-peptide cyclotransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0017186 | biological_process | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PBD A 401 |
| Chain | Residue |
| A | ASP144 |
| A | HOH709 |
| A | GLU183 |
| A | ASP238 |
| A | LEU239 |
| A | ILE295 |
| A | GLU296 |
| A | PHE317 |
| A | TRP321 |
| A | HOH527 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q16769 |
| Chain | Residue | Details |
| A | GLU183 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:24598748 |
| Chain | Residue | Details |
| A | ASP238 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24598748, ECO:0007744|PDB:4MHN, ECO:0007744|PDB:4MHY |
| Chain | Residue | Details |
| A | HIS322 | |
| A | ASP144 | |
| A | GLU184 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN57 | |
| A | ASN288 |
