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4MGH

Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis

Functional Information from GO Data
ChainGOidnamespacecontents
A0004642molecular_functionphosphoribosylformylglycinamidine synthase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006164biological_processpurine nucleotide biosynthetic process
A0006189biological_process'de novo' IMP biosynthetic process
A0006541biological_processglutamine metabolic process
A0016874molecular_functionligase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE ADP A 1301
ChainResidue
AVAL333
AASP679
AGLU718
AASN722
ASER886
AMG1302
AMG1303
AMG1304
AHOH1414
AHOH1448
AHOH1460
ATHR386
AHOH1479
AHOH1504
AHOH1698
AHOH1812
AHOH1833
AHOH1899
AHOH1904
AHOH1906
AGLY387
ATYR388
ALYS649
ALEU652
AGLN668
APRO676
AALA678

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1302
ChainResidue
AASP679
AASN722
AASP884
AADP1301
AHOH1904

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1303
ChainResidue
AGLU718
AADP1301
AHOH1460
AHOH1479
AHOH1833

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1304
ChainResidue
AGLU896
AADP1301
AHOH1448
AHOH1698
AHOH1899

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE MG A 1305
ChainResidue
ATYR251

site_idAC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE MN A 1306
ChainResidue
AHIS835

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1307
ChainResidue
AHIS216
AGLY504
AALA505
ALYS776
AHOH1477

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1308
ChainResidue
AHIS216
ATHR295
AHIS296
AASN297
AHIS298
ASER778
AHOH1557
AHOH1666

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1309
ChainResidue
AGLN1176
AGLY1184
AMET1185
AVAL1186
AHOH1606
AHOH1800
AHOH1876

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1310
ChainResidue
APRO1040
ALYS1041
AHIS1086
AHOH1535
AHOH1749

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1311
ChainResidue
AHIS1086
AARG1126
APRO1127
AGLN1128

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1312
ChainResidue
AASN1113
AARG1115

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1313
ChainResidue
AGLY913
AASP914
AASP915

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1314
ChainResidue
ATRP305
AARG1159
AARG1164
AHOH1522
AHOH1771
AHOH1798

site_idBC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1315
ChainResidue
ASER12
AALA13
APHE14
AASN998
AHIS1161

site_idBC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1316
ChainResidue
AILE633
AHOH1590

site_idBC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1317
ChainResidue
AARG1145
AARG1156
AARG1204

site_idBC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1318
ChainResidue
ATHR581
AGLU582
AGLU583

site_idCC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1319
ChainResidue
ALYS1228
AVAL1229
AHOH1576
AHOH1708
AHOH1856
ATYR690
AARG812

site_idCC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT A 1320
ChainResidue
AVAL438
AGLY441
APRO442
AALA443
AILE530
ALEU531
AARG550
AHOH1615

site_idCC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ACT A 1321
ChainResidue
AARG1221

site_idCC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT A 1322
ChainResidue
AGLU648
ATHR650
AGLN674
AGLU1005
ALYS1009
AHOH1524

site_idCC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ACT A 1323
ChainResidue
AHIS68
ATHR69

site_idCC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE XE A 1325
ChainResidue
ATHR683
AGLU693

site_idCC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE XE A 1327
ChainResidue
ALYS878

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00419
ChainResidueDetails
ACYG1135

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00419
ChainResidueDetails
AGLU1262
AHIS1260

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00419
ChainResidueDetails
AGLY307

site_idSWS_FT_FI4
Number of Residues3
DetailsBINDING:
ChainResidueDetails
ASER886
ATHR386
AALA678

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728
ChainResidueDetails
AGLU718
AASN722
AASP884
AASP679

221051

PDB entries from 2024-06-12

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