Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4M9Z

Crystal structure of CED-4 bound CED-3 fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006915	biological_process	apoptotic process
A	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
A	0008303	cellular_component	caspase complex
A	0008361	biological_process	regulation of cell size
A	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
A	0009792	biological_process	embryo development ending in birth or egg hatching
A	0010954	biological_process	positive regulation of protein processing
A	0016020	cellular_component	membrane
A	0016505	molecular_function	peptidase activator activity involved in apoptotic process
A	0030042	biological_process	actin filament depolymerization
A	0030155	biological_process	regulation of cell adhesion
A	0031647	biological_process	regulation of protein stability
A	0032991	cellular_component	protein-containing complex
A	0040034	biological_process	regulation of development, heterochronic
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043531	molecular_function	ADP binding
A	0046716	biological_process	muscle cell cellular homeostasis
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048598	biological_process	embryonic morphogenesis
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0051432	molecular_function	BH1 domain binding
A	0051434	molecular_function	BH3 domain binding
A	0061133	molecular_function	endopeptidase activator activity
A	0089720	molecular_function	caspase binding
A	0097202	biological_process	activation of cysteine-type endopeptidase activity
A	1900118	biological_process	negative regulation of execution phase of apoptosis
A	1902742	biological_process	apoptotic process involved in development
A	1904747	biological_process	positive regulation of apoptotic process involved in development
A	1905808	biological_process	positive regulation of synapse pruning
B	0000287	molecular_function	magnesium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006915	biological_process	apoptotic process
B	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
B	0008303	cellular_component	caspase complex
B	0008361	biological_process	regulation of cell size
B	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
B	0009792	biological_process	embryo development ending in birth or egg hatching
B	0010954	biological_process	positive regulation of protein processing
B	0016020	cellular_component	membrane
B	0016505	molecular_function	peptidase activator activity involved in apoptotic process
B	0030042	biological_process	actin filament depolymerization
B	0030155	biological_process	regulation of cell adhesion
B	0031647	biological_process	regulation of protein stability
B	0032991	cellular_component	protein-containing complex
B	0040034	biological_process	regulation of development, heterochronic
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043531	molecular_function	ADP binding
B	0046716	biological_process	muscle cell cellular homeostasis
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048598	biological_process	embryonic morphogenesis
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0051432	molecular_function	BH1 domain binding
B	0051434	molecular_function	BH3 domain binding
B	0061133	molecular_function	endopeptidase activator activity
B	0089720	molecular_function	caspase binding
B	0097202	biological_process	activation of cysteine-type endopeptidase activity
B	1900118	biological_process	negative regulation of execution phase of apoptosis
B	1902742	biological_process	apoptotic process involved in development
B	1904747	biological_process	positive regulation of apoptotic process involved in development
B	1905808	biological_process	positive regulation of synapse pruning
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
C	0008303	cellular_component	caspase complex
C	0008361	biological_process	regulation of cell size
C	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0010954	biological_process	positive regulation of protein processing
C	0016020	cellular_component	membrane
C	0016505	molecular_function	peptidase activator activity involved in apoptotic process
C	0030042	biological_process	actin filament depolymerization
C	0030155	biological_process	regulation of cell adhesion
C	0031647	biological_process	regulation of protein stability
C	0032991	cellular_component	protein-containing complex
C	0040034	biological_process	regulation of development, heterochronic
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043531	molecular_function	ADP binding
C	0046716	biological_process	muscle cell cellular homeostasis
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048598	biological_process	embryonic morphogenesis
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0051432	molecular_function	BH1 domain binding
C	0051434	molecular_function	BH3 domain binding
C	0061133	molecular_function	endopeptidase activator activity
C	0089720	molecular_function	caspase binding
C	0097202	biological_process	activation of cysteine-type endopeptidase activity
C	1900118	biological_process	negative regulation of execution phase of apoptosis
C	1902742	biological_process	apoptotic process involved in development
C	1904747	biological_process	positive regulation of apoptotic process involved in development
C	1905808	biological_process	positive regulation of synapse pruning
D	0000287	molecular_function	magnesium ion binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006915	biological_process	apoptotic process
D	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
D	0008303	cellular_component	caspase complex
D	0008361	biological_process	regulation of cell size
D	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
D	0009792	biological_process	embryo development ending in birth or egg hatching
D	0010954	biological_process	positive regulation of protein processing
D	0016020	cellular_component	membrane
D	0016505	molecular_function	peptidase activator activity involved in apoptotic process
D	0030042	biological_process	actin filament depolymerization
D	0030155	biological_process	regulation of cell adhesion
D	0031647	biological_process	regulation of protein stability
D	0032991	cellular_component	protein-containing complex
D	0040034	biological_process	regulation of development, heterochronic
D	0042802	molecular_function	identical protein binding
D	0042981	biological_process	regulation of apoptotic process
D	0043065	biological_process	positive regulation of apoptotic process
D	0043531	molecular_function	ADP binding
D	0046716	biological_process	muscle cell cellular homeostasis
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048598	biological_process	embryonic morphogenesis
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0051432	molecular_function	BH1 domain binding
D	0051434	molecular_function	BH3 domain binding
D	0061133	molecular_function	endopeptidase activator activity
D	0089720	molecular_function	caspase binding
D	0097202	biological_process	activation of cysteine-type endopeptidase activity
D	1900118	biological_process	negative regulation of execution phase of apoptosis
D	1902742	biological_process	apoptotic process involved in development
D	1904747	biological_process	positive regulation of apoptotic process involved in development
D	1905808	biological_process	positive regulation of synapse pruning

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	SER166
A	ASP250
A	THR271
A	ATP602

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP A 602

Chain	Residue
A	SER166
A	VAL167
A	ARG273
A	PHE301
A	TYR305
A	PRO330
A	ALA331
A	MSE334
A	PRO368
A	TYR369
A	MG601
A	MSE128
A	TYR131
A	GLY162
A	GLY164
A	LYS165

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 601

Chain	Residue
B	SER166
B	ASP250
B	ATP602

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP B 602

Chain	Residue
B	MSE128
B	TYR131
B	GLY162
B	GLY164
B	LYS165
B	SER166
B	VAL167
B	ARG273
B	PHE301
B	TYR305
B	PRO330
B	ALA331
B	MSE334
B	THR367
B	PRO368
B	TYR369
B	MG601

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 601

Chain	Residue
C	SER166
C	LYS191
C	ATP602

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP C 602

Chain	Residue
C	MSE128
C	TYR131
C	GLY162
C	GLY164
C	LYS165
C	SER166
C	VAL167
C	ARG273
C	PHE301
C	TYR305
C	PRO330
C	ALA331
C	MSE334
C	THR367
C	PRO368
C	TYR369
C	MG601

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 601

Chain	Residue
D	SER166
D	ASP250
D	THR271
D	ATP602

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP D 602

Chain	Residue
D	MSE128
D	TYR131
D	GLY162
D	GLY164
D	LYS165
D	SER166
D	VAL167
D	ARG273
D	PHE301
D	PRO330
D	ALA331
D	MSE334
D	THR367
D	PRO368
D	TYR369
D	MG601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:16208361, ECO:0000269\|PubMed:20434985, ECO:0000269\|PubMed:24065769, ECO:0007744\|PDB:2A5Y, ECO:0007744\|PDB:3LQQ, ECO:0007744\|PDB:3LQR, ECO:0007744\|PDB:4M9S, ECO:0007744\|PDB:4M9X, ECO:0007744\|PDB:4M9Y, ECO:0007744\|PDB:4M9Z

Chain	Residue	Details
A	TYR131
A	GLY162
B	TYR131
B	GLY162
C	TYR131
C	GLY162
D	TYR131
D	GLY162

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:16208361, ECO:0000269\|PubMed:20434985

Chain	Residue	Details
A	SER166
B	SER166
C	SER166
D	SER166

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:24065769, ECO:0007744\|PDB:4M9S

Chain	Residue	Details
A	GLN171
B	GLN171
C	GLN171
D	GLN171

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)