Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE RAR A 200 |
| Chain | Residue |
| A | ILE5 |
| A | MET50 |
| A | LEU55 |
| A | ARG58 |
| A | GLY97 |
| A | THR116 |
| A | NAP201 |
| A | HOH317 |
| A | TRP6 |
| A | ALA7 |
| A | GLY18 |
| A | LEU20 |
| A | ASP27 |
| A | LEU28 |
| A | PHE31 |
| A | LYS32 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP A 201 |
| Chain | Residue |
| A | TRP6 |
| A | ALA7 |
| A | ILE14 |
| A | GLY15 |
| A | GLU17 |
| A | GLY18 |
| A | LYS19 |
| A | LEU20 |
| A | GLY43 |
| A | ARG44 |
| A | ALA45 |
| A | THR46 |
| A | ARG58 |
| A | THR59 |
| A | LEU63 |
| A | THR64 |
| A | SER65 |
| A | HIS78 |
| A | SER79 |
| A | VAL80 |
| A | GLY97 |
| A | GLY98 |
| A | GLY99 |
| A | SER100 |
| A | VAL101 |
| A | VAL102 |
| A | PHE103 |
| A | GLU105 |
| A | ASP125 |
| A | THR126 |
| A | RAR200 |
| A | HOH311 |
| A | HOH318 |
| A | HOH329 |
| A | HOH345 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkegkLPWhlpn.DlkfFkekT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
