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4M73

Mutant structure of methyltransferase from Streptomyces hygroscopicus

Functional Information from GO Data
ChainGOidnamespacecontents
A0008168molecular_functionmethyltransferase activity
A0009058biological_processbiosynthetic process
A0017000biological_processantibiotic biosynthetic process
A0032259biological_processmethylation
B0008168molecular_functionmethyltransferase activity
B0009058biological_processbiosynthetic process
B0017000biological_processantibiotic biosynthetic process
B0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE SAH A 401
ChainResidue
AGLY166
AARG219
APHE239
AMET240
AHOH504
AHOH505
AHOH523
AHOH658
AHOH694
AHOH883
AGLY168
AARG172
AASP189
AILE190
AALA191
AGLY216
AASP217
AALA218

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE M72 A 402
ChainResidue
ATRP99
AILE132
ACYS136
AMET240
AHIS243
AASP272
APHE287
APHE291
AHIS295
AFE403
AHOH627
AHOH718
AHOH896

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FE A 403
ChainResidue
AHIS243
AHIS295
AM72402
AHOH627
AHOH718
AHOH844

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HF2 A 404
ChainResidue
AASP309
APHE312
ACYS319
ALYS322
APHE334
AHOH554
BLEU305
BLYS322
BALA324
BHF2404

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA A 405
ChainResidue
AARG12

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA A 406
ChainResidue
ALYS44
ATHR80

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA A 407
ChainResidue
AHOH631

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA A 408
ChainResidue
AGLN113
BHOH662

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA A 409
ChainResidue
AASP306
AASP309
AHOH692
AHOH947
BASP306
BASP309
BHOH595

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 410
ChainResidue
AARG109
BGLN126
BASP128
BHOH576

site_idBC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IOD A 411
ChainResidue
AASP217

site_idBC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE SAH B 401
ChainResidue
BSER140
BGLY166
BGLY168
BARG172
BASP189
BILE190
BGLY216
BASP217
BALA218
BARG219
BPHE239
BMET240
BMET241
BHOH508
BHOH513
BHOH617

site_idBC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE M72 B 402
ChainResidue
BTRP99
BILE132
BCYS136
BMET240
BHIS243
BASP272
BPHE287
BHIS295
BFE403
BHOH719
BHOH766
BHOH770

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FE B 403
ChainResidue
BHIS243
BHIS295
BGLU300
BM72402
BHOH766
BHOH770

site_idBC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE HF2 B 404
ChainResidue
ALYS322
AALA324
AHF2404
BASP309
BPHE312
BCYS319
BLYS322
BHOH546

site_idBC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA B 405
ChainResidue
BARG12

site_idBC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA B 406
ChainResidue
BGLY78

site_idBC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA B 407
ChainResidue
BHOH656

site_idCC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA B 408
ChainResidue
BLYS44

site_idCC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA B 409
ChainResidue
AHOH812
BGLN113

site_idCC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA B 410
ChainResidue
BLYS123
BHOH749

site_idCC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA B 411
ChainResidue
BASP217
BVAL224
BHOH833

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PDB entries from 2024-10-30

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