4M71

Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-homocysteine and methylphenylpyruvic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0017000	biological_process	antibiotic biosynthetic process
A	0032259	biological_process	methylation
B	0008168	molecular_function	methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0017000	biological_process	antibiotic biosynthetic process
B	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH A 401

Chain	Residue
A	GLY166
A	ARG219
A	PHE239
A	MET240
A	HOH512
A	HOH517
A	HOH520
A	HOH590
A	HOH620
A	HOH682
A	GLY168
A	ARG172
A	ASP189
A	ILE190
A	ALA191
A	GLY216
A	ASP217
A	ALA218

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 56D A 402

Chain	Residue
A	TRP99
A	CYS136
A	MET240
A	HIS243
A	ASP272
A	PHE287
A	PHE291
A	HIS295
A	FE403
A	HOH537
A	HOH564

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE A 403

Chain	Residue
A	HIS243
A	HIS295
A	56D402
A	HOH537
A	HOH564
A	HOH738

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HF2 A 404

Chain	Residue
A	ASP309
A	PHE312
A	CYS319
A	LYS322
A	PHE334
A	HOH551
A	HOH762
B	LEU305
B	LYS322
B	ALA324
B	HF2404

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 405

Chain	Residue
A	ARG12

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 406

Chain	Residue
A	LYS44

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 407

Chain	Residue
A	ARG75
A	HOH758
A	HOH782

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 408

Chain	Residue
A	ARG110

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 409

Chain	Residue
A	GLY182
A	HOH754

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 410

Chain	Residue
A	GLY228
A	PHE230
A	HOH809

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 411

Chain	Residue
A	VAL265

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 412

Chain	Residue
A	ASP306
A	ASP309
A	HOH676
B	ASP306
B	ASP309
B	HOH658

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 413

Chain	Residue
A	GLN113

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 414

Chain	Residue
A	ASP217
A	THR220

---

site_id	BC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH B 401

Chain	Residue
B	SER140
B	GLY166
B	GLY168
B	ARG172
B	ASP189
B	ILE190
B	GLY216
B	ASP217
B	ALA218
B	ARG219
B	PHE239
B	MET240
B	MET241
B	GLU244
B	HOH507
B	HOH516
B	HOH573

---

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 56D B 402

Chain	Residue
B	TRP99
B	CYS136
B	MET240
B	HIS243
B	ASP272
B	PHE287
B	HIS295
B	FE403
B	HOH598

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE B 403

Chain	Residue
B	HIS243
B	HIS295
B	56D402
B	HOH598
B	HOH620

---

site_id	BC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HF2 B 404

Chain	Residue
A	ALA324
A	HF2404
A	HOH676
B	ASP309
B	PHE312
B	CYS319
B	VAL320
B	LYS321
B	LYS322
B	HOH570
A	LYS322

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 406

Chain	Residue
B	ARG12

---

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 407

Chain	Residue
B	GLN113

---

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 408

Chain	Residue
B	LYS44

---

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 409

Chain	Residue
B	ASP217

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