4M6R

Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006915	biological_process	apoptotic process
A	0008270	molecular_function	zinc ion binding
A	0008652	biological_process	amino acid biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0016829	molecular_function	lyase activity
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0046570	molecular_function	methylthioribulose 1-phosphate dehydratase activity
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0070269	biological_process	pyroptotic inflammatory response
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006915	biological_process	apoptotic process
B	0008270	molecular_function	zinc ion binding
B	0008652	biological_process	amino acid biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0016829	molecular_function	lyase activity
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0046570	molecular_function	methylthioribulose 1-phosphate dehydratase activity
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0070269	biological_process	pyroptotic inflammatory response
B	0070372	biological_process	regulation of ERK1 and ERK2 cascade
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0008270	molecular_function	zinc ion binding
C	0008652	biological_process	amino acid biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0016829	molecular_function	lyase activity
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0046570	molecular_function	methylthioribulose 1-phosphate dehydratase activity
C	0046872	molecular_function	metal ion binding
C	0051289	biological_process	protein homotetramerization
C	0070269	biological_process	pyroptotic inflammatory response
C	0070372	biological_process	regulation of ERK1 and ERK2 cascade
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006915	biological_process	apoptotic process
D	0008270	molecular_function	zinc ion binding
D	0008652	biological_process	amino acid biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0016829	molecular_function	lyase activity
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0046570	molecular_function	methylthioribulose 1-phosphate dehydratase activity
D	0046872	molecular_function	metal ion binding
D	0051289	biological_process	protein homotetramerization
D	0070269	biological_process	pyroptotic inflammatory response
D	0070372	biological_process	regulation of ERK1 and ERK2 cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS115
A	HIS117
A	HIS195
A	HOH425
A	HOH481
D	HOH446

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	HIS195
B	HOH492
B	HOH494
A	HOH486
B	HIS115
B	HIS117

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN C 301

Chain	Residue
B	HOH424
C	HIS115
C	HIS117
C	HIS195
C	HOH443
C	HOH448

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 301

Chain	Residue
C	HOH418
D	HIS115
D	HIS117
D	HIS195
D	HOH415
D	HOH462

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03116","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24367089","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03116","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24367089","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03116","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24367089","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4M6R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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