4M69
Crystal structure of the mouse RIP3-MLKL complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ANP A 401 |
| Chain | Residue |
| A | VAL28 |
| A | LYS51 |
| A | THR95 |
| A | ARG96 |
| A | PHE97 |
| A | MET98 |
| A | SER102 |
| A | ASP143 |
| A | LYS145 |
| A | SER147 |
| A | ASN148 |
| A | GLY29 |
| A | LEU150 |
| A | ASP161 |
| A | MG403 |
| A | HOH526 |
| A | HOH551 |
| A | HOH574 |
| A | HOH583 |
| A | HOH584 |
| A | HOH594 |
| A | LYS30 |
| A | GLY31 |
| A | GLY32 |
| A | PHE33 |
| A | GLY34 |
| A | VAL36 |
| A | ALA49 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | ARG69 |
| A | ASN70 |
| A | GLU71 |
| A | VAL73 |
| A | LEU75 |
| A | ARG96 |
| A | LYS158 |
| A | HOH528 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 403 |
| Chain | Residue |
| A | ASN148 |
| A | ASP161 |
| A | ANP401 |
| A | HOH593 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 404 |
| Chain | Residue |
| A | ASP86 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 405 |
| Chain | Residue |
| A | ARG42 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | PRO215 |
| B | ARG301 |
| B | ARG304 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGGFGVVFrAhhrtwnhd..........VAVK |
| Chain | Residue | Details |
| A | VAL28-LYS51 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHrDLKpsNILL |
| Chain | Residue | Details |
| A | LEU139-LEU151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"10490590","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24095729","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24095729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4M69","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24095729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4M69","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23612963","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9Y572","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q9Y572","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"23612963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27819682","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"23612963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27819682","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23612963","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
