4M5X

Crystal structure of the USP7/HAUSP catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 601

Chain	Residue
A	HOH787
A	HOH798

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 602

Chain	Residue
A	GLN219
A	GLY275
A	LYS277

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 601

Chain	Residue
B	GLN219
B	GLY275
B	LYS277

---

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknqGAtCYMNSlLQ

Chain	Residue	Details
A	GLY215-GLN230

---

site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YiLhAVlvHsGdnhg..GHY

Chain	Residue	Details
A	TYR448-TYR465

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:12507430, ECO:0000269|PubMed:25944111, ECO:0000305|PubMed:11923872, ECO:0000305|PubMed:15053880, ECO:0000305|PubMed:16964248, ECO:0000305|PubMed:18716620, ECO:0000305|PubMed:21745816, ECO:0000305|PubMed:22411829

Chain	Residue	Details
A	CYS223
B	CYS223

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:12507430

Chain	Residue	Details
A	HIS464
B	HIS464

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 789

Chain	Residue	Details
A	ASN218	electrostatic stabiliser
A	CYS223	nucleofuge, nucleophile, proton acceptor, proton donor
A	HIS464	proton acceptor, proton donor
A	ASP481	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 789

Chain	Residue	Details
B	ASN218	electrostatic stabiliser
B	CYS223	nucleofuge, nucleophile, proton acceptor, proton donor
B	HIS464	proton acceptor, proton donor
B	ASP481	electrostatic stabiliser

---