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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4M48

X-ray structure of dopamine transporter elucidates antidepressant mechanism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 701

Chain	Residue
A	ALA44
A	ASP46
A	ASN49
A	SER320
A	ASN352
A	HOH809

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 702

Chain	Residue
A	LEU417
A	ASP420
A	SER421
A	GLY42
A	VAL45
A	ASP46

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 703

Chain	Residue
A	TYR69
A	GLN316
A	SER320
A	SER356

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 21B A 704

Chain	Residue
A	PHE43
A	ASP46
A	VAL120
A	ASP121
A	TYR124
A	PHE319
A	PHE325
A	SER421
A	GLY425
A	ALA479

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CLR A 705

Chain	Residue
A	LEU37
A	LEU270
A	TYR273
A	LEU277
A	ILE351

Functional Information from PROSITE/UniProt

site_id	PS00610
Number of Residues	15
Details	NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF

Chain	Residue	Details
A	TRP51-PHE65

site_id	PS00754
Number of Residues	21
Details	NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. FFfaSFTnsLPWtsCnniwNT

Chain	Residue	Details
A	PHE134-THR154

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR193-HIS199

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	VAL34-LYS59

site_id	SWS_FT_FI2
Number of Residues	164
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	ASN60-GLY63
A	PHE139-ILE278
A	THR285-GLU308
A	SER365-THR404
A	GLY467
A	ALA548-TYR550

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	ALA64-LEU87

site_id	SWS_FT_FI4
Number of Residues	69
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	GLY88-LYS107
A	GLY257-SER259
A	ASN335-ASN340
A	THR431-GLU445
A	SER495-ARG524

site_id	SWS_FT_FI5
Number of Residues	30
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	GLY108-SER138

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	LYS236-LYS256

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25961798, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	THR260-LEU284

site_id	SWS_FT_FI8
Number of Residues	25
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	VAL309-TYR334

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	VAL341-PHE364

site_id	SWS_FT_FI10
Number of Residues	25
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	PHE405-ILE430

site_id	SWS_FT_FI11
Number of Residues	20
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	LEU446-GLY466

site_id	SWS_FT_FI12
Number of Residues	26
Details	TRANSMEM: Helical; Name=10 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	PHE468-VAL494

site_id	SWS_FT_FI13
Number of Residues	22
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	PHE525-TYR547

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245

Chain	Residue	Details
A	VAL551-ILE571

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:24037379, ECO:0000269\|PubMed:25970245, ECO:0007744\|PDB:4XP1

Chain	Residue	Details
A	GLY42
A	ALA44
A	VAL45
A	ASN49
A	SER320
A	ASN352
A	LEU417
A	ASP420
A	SER421

site_id	SWS_FT_FI16
Number of Residues	3
Details	BINDING: BINDING => ECO:0007744\|PDB:4XP1

Chain	Residue	Details
A	ASP46
A	ALA117
A	ASP121

site_id	SWS_FT_FI17
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269\|PubMed:25970245, ECO:0007744\|PDB:4XP1

Chain	Residue	Details
A	ASN141

site_id	SWS_FT_FI18
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	GLY207
A	PHE216
A	ARG225
A	ASP231
A	LYS236
A	ASN224
A	ASN300

218853

PDB entries from 2024-04-24

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