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4M2T

Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001666biological_processresponse to hypoxia
A0001890biological_processplacenta development
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007507biological_processheart development
A0007565biological_processfemale pregnancy
A0007595biological_processlactation
A0007623biological_processcircadian rhythm
A0008559molecular_functionABC-type xenobiotic transporter activity
A0008585biological_processfemale gonad development
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0009914biological_processhormone transport
A0010046biological_processresponse to mycotoxin
A0010467biological_processgene expression
A0010498biological_processproteasomal protein catabolic process
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0031526cellular_componentbrush border membrane
A0031667biological_processresponse to nutrient levels
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032570biological_processresponse to progesterone
A0033189biological_processresponse to vitamin A
A0033280biological_processresponse to vitamin D
A0033762biological_processresponse to glucagon
A0035633biological_processmaintenance of blood-brain barrier
A0035932biological_processaldosterone secretion
A0036146biological_processcellular response to mycotoxin
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043215biological_processdaunorubicin transport
A0045177cellular_componentapical part of cell
A0045332biological_processphospholipid translocation
A0046581cellular_componentintercellular canaliculus
A0046686biological_processresponse to cadmium ion
A0046865biological_processterpenoid transport
A0050892biological_processintestinal absorption
A0055007biological_processcardiac muscle cell differentiation
A0055085biological_processtransmembrane transport
A0060856biological_processestablishment of blood-brain barrier
A0071217biological_processcellular response to external biotic stimulus
A0071222biological_processcellular response to lipopolysaccharide
A0071236biological_processcellular response to antibiotic
A0071312biological_processcellular response to alkaloid
A0071356biological_processcellular response to tumor necrosis factor
A0071392biological_processcellular response to estradiol stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071548biological_processresponse to dexamethasone
A0071549biological_processcellular response to dexamethasone stimulus
A0090554molecular_functionphosphatidylcholine floppase activity
A0090555molecular_functionphosphatidylethanolamine flippase activity
A0097068biological_processresponse to thyroxine
A0097305biological_processresponse to alcohol
A0097327biological_processresponse to antineoplastic agent
A0099038molecular_functionceramide floppase activity
A0099040biological_processceramide translocation
A0140115biological_processexport across plasma membrane
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A1902065biological_processresponse to L-glutamate
A1902396biological_processprotein localization to bicellular tight junction
A1903416biological_processresponse to glycoside
A1904057biological_processnegative regulation of sensory perception of pain
A1904148biological_processcellular response to nonylphenol
A1904446biological_processpositive regulation of establishment of Sertoli cell barrier
A1904478biological_processregulation of intestinal absorption
A1905231biological_processcellular response to borneol
A1905232biological_processcellular response to L-glutamate
A1905233biological_processresponse to codeine
A1905235biological_processresponse to quercetin
A1905237biological_processresponse to cyclosporin A
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
A1990962biological_processxenobiotic transport across blood-brain barrier
A1990963biological_processestablishment of blood-retinal barrier
A2001025biological_processpositive regulation of response to drug
B0000166molecular_functionnucleotide binding
B0001666biological_processresponse to hypoxia
B0001890biological_processplacenta development
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0007173biological_processepidermal growth factor receptor signaling pathway
B0007507biological_processheart development
B0007565biological_processfemale pregnancy
B0007595biological_processlactation
B0007623biological_processcircadian rhythm
B0008559molecular_functionABC-type xenobiotic transporter activity
B0008585biological_processfemale gonad development
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0009914biological_processhormone transport
B0010046biological_processresponse to mycotoxin
B0010467biological_processgene expression
B0010498biological_processproteasomal protein catabolic process
B0015562molecular_functionefflux transmembrane transporter activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016887molecular_functionATP hydrolysis activity
B0022857molecular_functiontransmembrane transporter activity
B0031526cellular_componentbrush border membrane
B0031667biological_processresponse to nutrient levels
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0032570biological_processresponse to progesterone
B0033189biological_processresponse to vitamin A
B0033280biological_processresponse to vitamin D
B0033762biological_processresponse to glucagon
B0035633biological_processmaintenance of blood-brain barrier
B0035932biological_processaldosterone secretion
B0036146biological_processcellular response to mycotoxin
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042908biological_processxenobiotic transport
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0043215biological_processdaunorubicin transport
B0045177cellular_componentapical part of cell
B0045332biological_processphospholipid translocation
B0046581cellular_componentintercellular canaliculus
B0046686biological_processresponse to cadmium ion
B0046865biological_processterpenoid transport
B0050892biological_processintestinal absorption
B0055007biological_processcardiac muscle cell differentiation
B0055085biological_processtransmembrane transport
B0060856biological_processestablishment of blood-brain barrier
B0071217biological_processcellular response to external biotic stimulus
B0071222biological_processcellular response to lipopolysaccharide
B0071236biological_processcellular response to antibiotic
B0071312biological_processcellular response to alkaloid
B0071356biological_processcellular response to tumor necrosis factor
B0071392biological_processcellular response to estradiol stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071548biological_processresponse to dexamethasone
B0071549biological_processcellular response to dexamethasone stimulus
B0090554molecular_functionphosphatidylcholine floppase activity
B0090555molecular_functionphosphatidylethanolamine flippase activity
B0097068biological_processresponse to thyroxine
B0097305biological_processresponse to alcohol
B0097327biological_processresponse to antineoplastic agent
B0099038molecular_functionceramide floppase activity
B0099040biological_processceramide translocation
B0140115biological_processexport across plasma membrane
B0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
B0140328molecular_functionfloppase activity
B0140359molecular_functionABC-type transporter activity
B1902065biological_processresponse to L-glutamate
B1902396biological_processprotein localization to bicellular tight junction
B1903416biological_processresponse to glycoside
B1904057biological_processnegative regulation of sensory perception of pain
B1904148biological_processcellular response to nonylphenol
B1904446biological_processpositive regulation of establishment of Sertoli cell barrier
B1904478biological_processregulation of intestinal absorption
B1905231biological_processcellular response to borneol
B1905232biological_processcellular response to L-glutamate
B1905233biological_processresponse to codeine
B1905235biological_processresponse to quercetin
B1905237biological_processresponse to cyclosporin A
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B1990962biological_processxenobiotic transport across blood-brain barrier
B1990963biological_processestablishment of blood-retinal barrier
B2001025biological_processpositive regulation of response to drug
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2J8 A 6001
ChainResidue
APHE299
A2J86002
ATYR303
ATYR306
ALEU335
AILE336
APHE339
ALEU720
AGLN721
AGLN986

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 2J8 A 6002
ChainResidue
ALEU64
AMET68
APHE71
APHE332
ATYR949
APHE974
APHE979
AMET982
A2J86001

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2J8 B 6003
ChainResidue
BMET295
BPHE299
BILE302
BTYR303
BTYR306
BLEU335
BPHE339
BGLN721
BALA983
BGLN986

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 2J8 B 6004
ChainResidue
BLEU64
BMET68
BPHE332
BMET945
BTYR949
BPHE974
BPHE979
BMET982

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
ChainResidueDetails
ALEU527-LEU541
ALEU1172-LEU1186

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues494
DetailsTransmembrane: {"description":"Helical"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues206
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues436
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues606
DetailsDomain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues472
DetailsDomain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues578
DetailsDomain: {"description":"ABC transmembrane type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues476
DetailsDomain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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