Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4M0L

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus complexed with GDP

Replaces: 3P3M

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000049	molecular_function	tRNA binding
B	0001731	biological_process	formation of translation preinitiation complex
B	0003743	molecular_function	translation initiation factor activity
B	0003746	molecular_function	translation elongation factor activity
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0006414	biological_process	translational elongation
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000049	molecular_function	tRNA binding
C	0001731	biological_process	formation of translation preinitiation complex
C	0003743	molecular_function	translation initiation factor activity
C	0003746	molecular_function	translation elongation factor activity
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006414	biological_process	translational elongation
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000049	molecular_function	tRNA binding
D	0001731	biological_process	formation of translation preinitiation complex
D	0003743	molecular_function	translation initiation factor activity
D	0003746	molecular_function	translation elongation factor activity
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006414	biological_process	translational elongation
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0000049	molecular_function	tRNA binding
E	0001731	biological_process	formation of translation preinitiation complex
E	0003743	molecular_function	translation initiation factor activity
E	0003746	molecular_function	translation elongation factor activity
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0006414	biological_process	translational elongation
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
F	0000049	molecular_function	tRNA binding
F	0001731	biological_process	formation of translation preinitiation complex
F	0003743	molecular_function	translation initiation factor activity
F	0003746	molecular_function	translation elongation factor activity
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0006414	biological_process	translational elongation
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP A 501

Chain	Residue
A	VAL18
A	VAL153
A	SER184
A	ALA185
A	LEU186
A	MG502
A	HOH632
A	HOH646
A	HOH657
A	ASP19
A	GLY21
A	LYS22
A	THR23
A	THR24
A	ASN149
A	LYS150
A	ASP152

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	THR23
A	GDP501
A	HOH632
A	HOH644
A	HOH645
A	HOH646

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GDP B 501

Chain	Residue
B	VAL18
B	ASP19
B	HIS20
B	GLY21
B	LYS22
B	THR23
B	THR24
B	ASN149
B	LYS150
B	ASP152
B	VAL153
B	SER184
B	ALA185
B	LEU186
B	MG502
B	HOH622
B	HOH645
B	HOH650

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 502

Chain	Residue
B	THR23
B	GDP501
B	HOH622
B	HOH625
B	HOH645

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP C 501

Chain	Residue
C	ASP19
C	HIS20
C	GLY21
C	LYS22
C	THR23
C	THR24
C	ASN149
C	LYS150
C	ASP152
C	SER184
C	ALA185
C	LEU186
C	MG502
C	HOH634
C	HOH643
C	HOH655

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 502

Chain	Residue
C	THR23
C	GDP501
C	HOH634
C	HOH643
C	HOH655
C	HOH665

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 503

Chain	Residue
C	THR54
C	THR70
C	GLU71
C	HOH607
C	HOH630

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP D 501

Chain	Residue
A	ARG404
D	ASP19
D	GLY21
D	LYS22
D	THR23
D	THR24
D	ASN149
D	LYS150
D	ASP152
D	VAL153
D	SER184
D	ALA185
D	LEU186
D	MG502
D	HOH617
D	HOH631
D	HOH650

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 502

Chain	Residue
D	THR23
D	GDP501
D	HOH617
D	HOH631
D	HOH632

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDP E 501

Chain	Residue
E	LYS22
E	THR23
E	THR24
E	ASN149
E	LYS150
E	ASP152
E	VAL153
E	SER184
E	ALA185
E	LEU186
E	MG502
E	HOH608
E	HOH621
E	HOH637
E	HOH638
E	HIS17
E	ASP19
E	HIS20
E	GLY21

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 502

Chain	Residue
E	THR23
E	GDP501
E	HOH621
E	HOH636
E	HOH637
E	HOH638

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 E 503

Chain	Residue
B	LEU326
B	TRP327
B	ASN328
E	TYR206
E	ARG207
E	ASP208

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP F 501

Chain	Residue
F	ASP19
F	HIS20
F	GLY21
F	LYS22
F	THR23
F	THR24
F	ASN149
F	LYS150
F	ASP152
F	VAL153
F	SER184
F	ALA185
F	LEU186
F	MG502
F	HOH619

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 502

Chain	Residue
F	THR23
F	GDP501
F	HOH606
F	HOH615
F	HOH619

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:4RD1

Chain	Residue	Details
A	ASP19
E	GLY44
F	ASP19
F	GLY44
A	GLY44
B	ASP19
B	GLY44
C	ASP19
C	GLY44
D	ASP19
D	GLY44
E	ASP19

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:16407071, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:2AHO

Chain	Residue	Details
A	THR23
E	THR46
F	THR23
F	THR46
A	THR46
B	THR23
B	THR46
C	THR23
C	THR46
D	THR23
D	THR46
E	THR23

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q8U082, ECO:0000255\|HAMAP-Rule:MF_00119

Chain	Residue	Details
A	CYS59
C	CYS62
C	CYS74
C	CYS77
D	CYS59
D	CYS62
D	CYS74
D	CYS77
E	CYS59
E	CYS62
E	CYS74
A	CYS62
E	CYS77
F	CYS59
F	CYS62
F	CYS74
F	CYS77
A	CYS74
A	CYS77
B	CYS59
B	CYS62
B	CYS74
B	CYS77
C	CYS59

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:4RCY, ECO:0007744\|PDB:4RD1

Chain	Residue	Details
A	ASN149
E	SER184
F	ASN149
F	SER184
A	SER184
B	ASN149
B	SER184
C	ASN149
C	SER184
D	ASN149
D	SER184
E	ASN149

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)