4LZZ
Nucleotide-induced asymmetry within atpase activator ring drives s54-RNAP interaction and ATP hydrolysis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008134 | molecular_function | transcription factor binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008134 | molecular_function | transcription factor binding |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008134 | molecular_function | transcription factor binding |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008134 | molecular_function | transcription factor binding |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008134 | molecular_function | transcription factor binding |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0008134 | molecular_function | transcription factor binding |
| G | 0016887 | molecular_function | ATP hydrolysis activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0008134 | molecular_function | transcription factor binding |
| H | 0016887 | molecular_function | ATP hydrolysis activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0006355 | biological_process | regulation of DNA-templated transcription |
| I | 0008134 | molecular_function | transcription factor binding |
| I | 0016887 | molecular_function | ATP hydrolysis activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0006355 | biological_process | regulation of DNA-templated transcription |
| J | 0008134 | molecular_function | transcription factor binding |
| J | 0016887 | molecular_function | ATP hydrolysis activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0006355 | biological_process | regulation of DNA-templated transcription |
| K | 0008134 | molecular_function | transcription factor binding |
| K | 0016887 | molecular_function | ATP hydrolysis activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0006355 | biological_process | regulation of DNA-templated transcription |
| L | 0008134 | molecular_function | transcription factor binding |
| L | 0016887 | molecular_function | ATP hydrolysis activity |
| M | 0005524 | molecular_function | ATP binding |
| M | 0006355 | biological_process | regulation of DNA-templated transcription |
| M | 0008134 | molecular_function | transcription factor binding |
| M | 0016887 | molecular_function | ATP hydrolysis activity |
| N | 0005524 | molecular_function | ATP binding |
| N | 0006355 | biological_process | regulation of DNA-templated transcription |
| N | 0008134 | molecular_function | transcription factor binding |
| N | 0016887 | molecular_function | ATP hydrolysis activity |
| O | 0005524 | molecular_function | ATP binding |
| O | 0006355 | biological_process | regulation of DNA-templated transcription |
| O | 0008134 | molecular_function | transcription factor binding |
| O | 0016887 | molecular_function | ATP hydrolysis activity |
| P | 0005524 | molecular_function | ATP binding |
| P | 0006355 | biological_process | regulation of DNA-templated transcription |
| P | 0008134 | molecular_function | transcription factor binding |
| P | 0016887 | molecular_function | ATP hydrolysis activity |
| Q | 0005524 | molecular_function | ATP binding |
| Q | 0006355 | biological_process | regulation of DNA-templated transcription |
| Q | 0008134 | molecular_function | transcription factor binding |
| Q | 0016887 | molecular_function | ATP hydrolysis activity |
| R | 0005524 | molecular_function | ATP binding |
| R | 0006355 | biological_process | regulation of DNA-templated transcription |
| R | 0008134 | molecular_function | transcription factor binding |
| R | 0016887 | molecular_function | ATP hydrolysis activity |
| S | 0005524 | molecular_function | ATP binding |
| S | 0006355 | biological_process | regulation of DNA-templated transcription |
| S | 0008134 | molecular_function | transcription factor binding |
| S | 0016887 | molecular_function | ATP hydrolysis activity |
| T | 0005524 | molecular_function | ATP binding |
| T | 0006355 | biological_process | regulation of DNA-templated transcription |
| T | 0008134 | molecular_function | transcription factor binding |
| T | 0016887 | molecular_function | ATP hydrolysis activity |
| U | 0005524 | molecular_function | ATP binding |
| U | 0006355 | biological_process | regulation of DNA-templated transcription |
| U | 0008134 | molecular_function | transcription factor binding |
| U | 0016887 | molecular_function | ATP hydrolysis activity |
| V | 0005524 | molecular_function | ATP binding |
| V | 0006355 | biological_process | regulation of DNA-templated transcription |
| V | 0008134 | molecular_function | transcription factor binding |
| V | 0016887 | molecular_function | ATP hydrolysis activity |
| W | 0005524 | molecular_function | ATP binding |
| W | 0006355 | biological_process | regulation of DNA-templated transcription |
| W | 0008134 | molecular_function | transcription factor binding |
| W | 0016887 | molecular_function | ATP hydrolysis activity |
| X | 0005524 | molecular_function | ATP binding |
| X | 0006355 | biological_process | regulation of DNA-templated transcription |
| X | 0008134 | molecular_function | transcription factor binding |
| X | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 08T A 400 |
| Chain | Residue |
| A | TYR139 |
| A | GLU239 |
| A | ASN280 |
| A | VAL356 |
| A | ARG357 |
| A | MG401 |
| B | ARG299 |
| A | VAL140 |
| A | MET146 |
| A | SER169 |
| A | GLY170 |
| A | GLY172 |
| A | LYS173 |
| A | GLU174 |
| A | ASP238 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | ASP238 |
| A | 08T400 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 08T B 400 |
| Chain | Residue |
| B | SER169 |
| B | GLY170 |
| B | VAL171 |
| B | GLY172 |
| B | LYS173 |
| B | GLU174 |
| B | ASP238 |
| B | GLU239 |
| B | ASN280 |
| B | VAL356 |
| B | ARG357 |
| B | MG401 |
| C | LEU252 |
| C | ASP295 |
| C | ARG299 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | ASP238 |
| B | GLU239 |
| B | 08T400 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 08T C 400 |
| Chain | Residue |
| C | VAL140 |
| C | SER169 |
| C | GLY170 |
| C | VAL171 |
| C | GLY172 |
| C | LYS173 |
| C | GLU174 |
| C | VAL175 |
| C | GLU239 |
| C | VAL356 |
| C | ARG357 |
| C | LYS360 |
| C | MG401 |
| D | ARG299 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 401 |
| Chain | Residue |
| C | ASP238 |
| C | 08T400 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 08T D 400 |
| Chain | Residue |
| D | TYR139 |
| D | VAL140 |
| D | SER169 |
| D | GLY170 |
| D | GLY172 |
| D | LYS173 |
| D | GLU174 |
| D | VAL356 |
| D | ARG357 |
| D | MG401 |
| E | ASP295 |
| E | ARG299 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 401 |
| Chain | Residue |
| D | ASP238 |
| D | 08T400 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 08T E 400 |
| Chain | Residue |
| E | TYR139 |
| E | SER169 |
| E | GLY170 |
| E | VAL171 |
| E | GLY172 |
| E | LYS173 |
| E | GLU174 |
| E | GLU239 |
| E | ASN280 |
| E | ARG313 |
| E | VAL356 |
| E | ARG357 |
| E | MG401 |
| F | ARG299 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E 401 |
| Chain | Residue |
| E | ASP238 |
| E | 08T400 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP F 400 |
| Chain | Residue |
| F | SER169 |
| F | GLY170 |
| F | VAL171 |
| F | GLY172 |
| F | LYS173 |
| F | GLU174 |
| F | VAL175 |
| F | ASP238 |
| F | GLU239 |
| F | LEU320 |
| F | PHE324 |
| F | VAL356 |
| F | ARG357 |
| F | MG401 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG F 401 |
| Chain | Residue |
| F | ASP238 |
| F | ADP400 |
| site_id | BC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 08T G 400 |
| Chain | Residue |
| G | SER169 |
| G | GLY170 |
| G | VAL171 |
| G | GLY172 |
| G | LYS173 |
| G | GLU174 |
| G | VAL175 |
| G | ASP238 |
| G | GLU239 |
| G | VAL356 |
| G | ARG357 |
| G | MG401 |
| H | ASP295 |
| H | ARG299 |
| G | VAL140 |
| G | MET146 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG G 401 |
| Chain | Residue |
| G | SER169 |
| G | ASP238 |
| G | 08T400 |
| site_id | BC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 08T H 400 |
| Chain | Residue |
| H | TYR139 |
| H | VAL140 |
| H | SER169 |
| H | GLY170 |
| H | GLY172 |
| H | LYS173 |
| H | GLU174 |
| H | VAL175 |
| H | ASP238 |
| H | GLU239 |
| H | ASN280 |
| H | VAL356 |
| H | ARG357 |
| H | MG401 |
| I | ASP295 |
| I | ARG299 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG H 401 |
| Chain | Residue |
| H | ASP238 |
| H | 08T400 |
| site_id | BC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 08T I 400 |
| Chain | Residue |
| I | VAL140 |
| I | SER169 |
| I | GLY170 |
| I | GLY172 |
| I | LYS173 |
| I | GLU174 |
| I | VAL175 |
| I | ASP238 |
| I | GLU239 |
| I | PHE324 |
| I | VAL356 |
| I | ARG357 |
| I | MG401 |
| J | GLU256 |
| J | ARG299 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG I 401 |
| Chain | Residue |
| I | ASP238 |
| I | 08T400 |
| site_id | CC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 08T J 400 |
| Chain | Residue |
| J | TYR139 |
| J | VAL140 |
| J | SER169 |
| J | GLY172 |
| J | LYS173 |
| J | GLU174 |
| J | GLU239 |
| J | ASN280 |
| J | VAL356 |
| J | ARG357 |
| J | MG401 |
| K | GLU256 |
| K | ASP295 |
| K | ARG299 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG J 401 |
| Chain | Residue |
| J | ASP238 |
| J | 08T400 |
| site_id | CC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 08T K 400 |
| Chain | Residue |
| K | TYR139 |
| K | VAL140 |
| K | SER169 |
| K | GLY170 |
| K | VAL171 |
| K | GLY172 |
| K | LYS173 |
| K | GLU174 |
| K | VAL175 |
| K | PHE324 |
| K | VAL356 |
| K | ARG357 |
| K | LYS360 |
| K | MG401 |
| L | GLU256 |
| L | ARG299 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG K 401 |
| Chain | Residue |
| K | LYS173 |
| K | GLU239 |
| K | 08T400 |
| site_id | CC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP L 400 |
| Chain | Residue |
| L | TYR139 |
| L | VAL140 |
| L | GLU168 |
| L | SER169 |
| L | GLY170 |
| L | VAL171 |
| L | GLY172 |
| L | LYS173 |
| L | GLU174 |
| L | VAL175 |
| L | ASP238 |
| L | GLU239 |
| L | VAL356 |
| L | ARG357 |
| L | LYS360 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG L 401 |
| Chain | Residue |
| L | GLU174 |
| L | ASP238 |
| site_id | CC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 08T M 400 |
| Chain | Residue |
| M | TYR139 |
| M | SER169 |
| M | GLY170 |
| M | GLY172 |
| M | LYS173 |
| M | GLU174 |
| M | ASP238 |
| M | GLU239 |
| M | ASN280 |
| M | PHE324 |
| M | VAL356 |
| M | ARG357 |
| N | ARG299 |
| site_id | CC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 08T N 400 |
| Chain | Residue |
| N | SER169 |
| N | GLY170 |
| N | VAL171 |
| N | GLY172 |
| N | LYS173 |
| N | GLU174 |
| N | VAL175 |
| N | ASP238 |
| N | GLU239 |
| N | ASN280 |
| N | LEU320 |
| N | VAL356 |
| N | ARG357 |
| N | MG401 |
| O | ASP295 |
| O | ARG299 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG N 401 |
| Chain | Residue |
| N | ASP238 |
| N | 08T400 |
| site_id | DC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 08T O 400 |
| Chain | Residue |
| O | VAL140 |
| O | SER169 |
| O | GLY172 |
| O | LYS173 |
| O | GLU174 |
| O | VAL175 |
| O | GLU239 |
| O | VAL356 |
| O | ARG357 |
| O | MG401 |
| P | GLU256 |
| P | ARG299 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG O 401 |
| Chain | Residue |
| O | GLU174 |
| O | ASP238 |
| O | 08T400 |
| site_id | DC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 08T P 400 |
| Chain | Residue |
| P | SER169 |
| P | GLY170 |
| P | GLY172 |
| P | LYS173 |
| P | GLU174 |
| P | GLU239 |
| P | ASN280 |
| P | VAL356 |
| P | ARG357 |
| P | MG401 |
| Q | GLU256 |
| Q | ARG299 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG P 401 |
| Chain | Residue |
| P | ASP238 |
| P | GLU239 |
| P | 08T400 |
| Q | ARG299 |
| site_id | DC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 08T Q 400 |
| Chain | Residue |
| Q | TYR139 |
| Q | VAL140 |
| Q | SER169 |
| Q | GLY170 |
| Q | VAL171 |
| Q | GLY172 |
| Q | LYS173 |
| Q | GLU174 |
| Q | GLU239 |
| Q | VAL356 |
| Q | ARG357 |
| Q | MG401 |
| R | GLU256 |
| R | ARG299 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG Q 401 |
| Chain | Residue |
| Q | ASP238 |
| Q | GLU239 |
| Q | 08T400 |
| site_id | DC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 08T R 400 |
| Chain | Residue |
| R | TYR139 |
| R | VAL140 |
| R | PHE141 |
| R | SER169 |
| R | GLY170 |
| R | VAL171 |
| R | GLY172 |
| R | LYS173 |
| R | GLU174 |
| R | VAL175 |
| R | ASP238 |
| R | GLU239 |
| R | ASN280 |
| R | LEU320 |
| R | PHE324 |
| R | VAL356 |
| R | ARG357 |
| R | LYS360 |
| R | MG401 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG R 401 |
| Chain | Residue |
| R | ASP238 |
| R | 08T400 |
| site_id | DC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 08T S 400 |
| Chain | Residue |
| S | TYR139 |
| S | VAL140 |
| S | SER169 |
| S | GLY170 |
| S | VAL171 |
| S | GLY172 |
| S | LYS173 |
| S | GLU174 |
| S | ASP238 |
| S | GLU239 |
| S | ASN280 |
| S | VAL356 |
| S | ARG357 |
| S | LYS360 |
| S | MG401 |
| T | ASP295 |
| T | ARG299 |
| site_id | EC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG S 401 |
| Chain | Residue |
| S | ASP238 |
| S | 08T400 |
| site_id | EC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 08T T 400 |
| Chain | Residue |
| T | SER169 |
| T | GLY170 |
| T | VAL171 |
| T | GLY172 |
| T | LYS173 |
| T | GLU174 |
| T | VAL175 |
| T | ASP238 |
| T | GLU239 |
| T | ASN280 |
| T | VAL356 |
| T | ARG357 |
| T | MG401 |
| U | LEU252 |
| U | ASP295 |
| U | ARG299 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG T 401 |
| Chain | Residue |
| T | ASP238 |
| T | GLU239 |
| T | 08T400 |
| site_id | EC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 08T U 400 |
| Chain | Residue |
| U | VAL140 |
| U | SER169 |
| U | GLY170 |
| U | GLY172 |
| U | LYS173 |
| U | GLU174 |
| U | VAL175 |
| U | GLU239 |
| U | PHE324 |
| U | VAL356 |
| U | ARG357 |
| U | LYS360 |
| U | MG401 |
| V | GLU256 |
| V | ARG299 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG U 401 |
| Chain | Residue |
| U | ASP238 |
| U | GLU239 |
| U | 08T400 |
| site_id | EC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 08T V 400 |
| Chain | Residue |
| V | TYR139 |
| V | VAL140 |
| V | SER169 |
| V | GLY170 |
| V | GLY172 |
| V | LYS173 |
| V | GLU174 |
| V | VAL175 |
| V | ASP238 |
| V | GLU239 |
| V | VAL356 |
| V | ARG357 |
| V | MG401 |
| W | GLU256 |
| W | ARG299 |
| site_id | EC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG V 401 |
| Chain | Residue |
| V | ASP238 |
| V | 08T400 |
| site_id | EC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 08T W 400 |
| Chain | Residue |
| W | TYR139 |
| W | VAL140 |
| W | SER169 |
| W | GLY170 |
| W | VAL171 |
| W | GLY172 |
| W | LYS173 |
| W | GLU174 |
| W | GLU239 |
| W | ASN280 |
| W | VAL356 |
| W | ARG357 |
| W | MG401 |
| X | GLU256 |
| X | ASP295 |
| X | ARG299 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG W 401 |
| Chain | Residue |
| W | ASP238 |
| W | GLU239 |
| W | 08T400 |
| site_id | FC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 08T X 400 |
| Chain | Residue |
| X | TYR139 |
| X | VAL140 |
| X | GLU168 |
| X | SER169 |
| X | GLY170 |
| X | VAL171 |
| X | GLY172 |
| X | LYS173 |
| X | GLU174 |
| X | VAL175 |
| X | ASP238 |
| X | GLU239 |
| X | ASN280 |
| X | LEU320 |
| X | PHE324 |
| X | VAL356 |
| X | ARG357 |
| X | MG401 |
| site_id | FC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG X 401 |
| Chain | Residue |
| X | ASP238 |
| X | GLU239 |
| X | 08T400 |
Functional Information from PROSITE/UniProt
| site_id | PS00675 |
| Number of Residues | 14 |
| Details | SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VLItGESGVGKevV |
| Chain | Residue | Details |
| A | VAL163-VAL176 |
| site_id | PS00676 |
| Number of Residues | 16 |
| Details | SIGMA54_INTERACT_2 Sigma-54 interaction domain ATP-binding region B signature. GfFelADGGTLFLDEI |
| Chain | Residue | Details |
| A | GLY225-ILE240 |
